Disque (anneau fibreux)
The annulus fibrosus is the outer layer of an intervertebral disc.
À propos de ce matériau
(En anglais seulement) The annulus fibrosus is the outer layer of an intervertebral disc. It is subjected to a combination of compressive, tensile and shear stresses. The annulus fibrosus is a layered structure of a solid porous matrix containing proteoglycan and a network of collagen fibers saturated with water. However, it is vulnerable to damage (tear) and has limited regenerative potential which leads to common spinal pathologies such as herniated discs. In order to treat lesions of the annulus fibrosus, constructs could provide functional equivalence with native tissues in both form and strength. Thus, mechanical testing of annulus fibrosus constructs will aid in the development of reliable techniques/protocols in tissue engineering of annulus fibrosus.
Configurations de test (9)
Indentation (Raideur)

Contrôle de la temperature
Stimulation Mécanique (Cisaillement)
Stimulation mécanique (compression)
Capteurs analogues externes
Flux de caméra
Positionnement (manuel)
Positionnement (X Auto)
Études de cas (1)
Ressources associées (3)
Littérature associée
Integrin inhibition facilitates fibrocartilaginous transformation in connective tissue in osteoarthritis
Ruiye Bi; Xianni Yang; Haohan Li; Yanjing Zhan; Qing Yin; Han Fang; Ziqian Wang; Binbin Ying; Haopeng Yu; Songsong Zhu
Science Advances, Vol 12, Issue 1, Published: 2 Jan 2026
4 citations · 4 en 2025–2026
Can UVA-light-activated riboflavin-induced collagen crosslinking be transferred from ophthalmology to spine surgery? A feasibility study on bovine intervertebral disc
Ioannis Vasilikos; Graciosa Q. Teixeira; Andreas Seitz; Julia Nothelfer; Julian Haas; Hans-Joachim Wilke; Boris Mizaikoff; Jürgen Beck; Ulrich Hubbe; Cornelia Neidlinger-Wilke
PLoS ONE 16(6): e0252672. https://doi.org/ 10.1371/journal.pone.0252672
5 citations · 2 en 2025–2026
Chitosan-based hydrogels supplemented with gelatine and Link N enhance extracellular matrix deposition by encapsulated cells in a degenerative intervertebral disc environment.
Laboratory for endovascular biomaterials (LBeV), CHUM research centre (CRCHUM), 900 St Denis St, Montreal, QC H2X 3H8, Canada; A Adoungotchodo; LM Epure; F Mwale; S Lerouge
Eur Cell Mater. 2021 May 4;41:471-484. doi: 10.22203/eCM.v041a30. PMID: 33945627.
17 citations · 8 en 2025–2026
Development of an In Vitro Outer Annulus Fibrosus Cartilage Endplate Model and its Response to Dynamic Mechanical Loading
Université de Toronto
Intervertebral disc implant
US Patent App. 10195044, 2019
Des changements dans la concentration de calcium altère les propriétés mécaniques du disque intervertébral
I. Hadjab; M.P. Grant; L.M. Epure; M. Garon; E. Quenneville; J. Anthoniou; F. Mwale; M.D. Buschmann
International Conference on the Mechanics of Biomaterials and Tissues, Hawaii, USA, 1 2 Dec 2017, Podium O.48. Presented by E. Quenneville
The Bioengineering of Annulus Fibrosus Tissues Using Phenotypically Distinct Inner and Outer Annulus Fibrosus Cells on Oriented Nanofibrous Polyurethane Scaffolds
PhD thesis, University of Toronto, 2017.
0 citations · 0 en 2025–2026
Changes in Collagen and Sulphated Proteoglycan Synthesis by Multilamellated AF Tissues Cultured in vitro on Aligned Nanofibrous Polyurethane Constructs Under Dynamic Compressive Loading
Presentation #331.2 on Fri May 20 from 16:30 to 18:30 in room 511E during the World Congress on Biomechanics, Montreal, May 2016.
Construction of a Tissue-Engineered Annulus Fibrosus
Hongsik Cho; Sang-Hyug Park; Kwideok Park; Joon Wan Shim; Jinsong Huang; Richard Smith; Steve Elder; Byoung-Hyun Min; Karen A. Hasty
Artificial Organs. 2013.
14 citations · 1 en 2025–2026
Assessment of mechanical properties of isolated bovine intervertebral discs from multi-parametric magnetic resonance imaging
Maximilien Recuerda; Delphine Périé; Guillaume Gilbert; Gilles Beaudoin
BMC Musculoskeletal Disorders. 2012;13:195.
30 citations · 1 en 2025–2026
Effect of circumferential constraint on nucleus pulposus tissue in vitro
Darla J. Hamilton; Robert M. Pilliar; Stephen Waldman; Rita A. Kandel
The Spine Journal. 2010.
6 citations · 1 en 2025–2026
Characterization of intervertebral disc mechanical properties and their relationships with quantitative magnetic resonance imaging
Polytechnique Montréal. MASc. 2010
Characterization of the mechanical properties of intervertebral discs and their relationships with quantitative magnetic resonance imaging [English translation]
École Polytechnique de Montréal, Université de Montréal. Master of Applied Science thesis. December 2010.
Characterization of a Biodegradable Electrospun Polyurethane Nanofiber Scaffold Suitable for Annulus Fibrosus Tissue Engineering
University of Toronto. Master of Applied Science and Engineering thesis. 2009.
0 citations · 0 en 2025–2026
Structure and Function of the Elastic Fibre Network of the Human Lumbar Anulus Fibrosus
University of Adelaide. Ph.D. thesis. 2008.
0 citations · 0 en 2025–2026
Elastic Fibers Enhance the Mechanical Integrity of the Human Lumbar Anulus Fibrosus in the Radial Direction
Lachlan J. Smith; Sharon Byers; John J. Costi; Nicola L. Fazzalari
Annals of Biomedical Engineering. 2008.
100 citations · 7 en 2025–2026
A fibril-network-reinforced biphasic model of cartilage in unconfined compression
J. Soulhat; M. D. Buschmann; A. Shirazi-Adl
Journal of Biomechanical Engineering, Jun, 121(3), 340-347. (1999)
250 citations · 9 en 2025–2026
FAQ
Comment fonctionne la fonction Creep (Fluage)?+
Qu'est-ce que la viscoélasticité?+
LAB MODULE – Torsion of Disk-Shaped Samples – Student Version
Qu'est-ce que l'élasticité?+
Module de laboratoire — Torsion de l’os
LAB MODULE – Unconfined Compression of Hydrogel Disks – Student Version

