The Bioengineering of Annulus Fibrosus Tissues Using Phenotypically Distinct Inner and Outer Annulus Fibrosus Cells on Oriented Nanofibrous Polyurethane Scaffolds

Editorial summary

This thesis investigates tissue-engineering strategies for replacing the intervertebral disc. Distinct annulus-fibrosus cell populations were cultured on oriented polymer scaffolds and combined with other engineered disc components. Biological and mechanical assessments evaluate formation and integration of a multiphasic replacement construct.