
(En anglais seulement) Confined compression testing measures the capacity of a material to withstand axial compressive loads without expanding perpendicularly to the force. Confined compression tests are usually performed on biphasic materials (one phase being liquid) (e.g. poroelastic materials). This test is generally conducted in a closed cylindrical chamber where the sample completely fills the chamber volume. A piston is used to apply stress to the sample. With the liquid phase being incompressible, at least one wall of the confined compression chamber must be porous to deform the material. The aggregate modulus (Ha) corresponds to the stiffness of the material at equilibrium when fluid has ceased flowing through it.
Testeur recommandé (1)

Accessoires (8)
Études de cas (2)
Ressources associées (4)
Littérature associée
Effects of Preservation on the Compressive Properties and Microstructure of the Knee Meniscus
Chester Jar; Abbi Oguchi; Mohammadhamed Shahsavari; Nadr M. Jomha; Lindsey Westover; Gail M. Thornton
Ann Biomed Eng (2026), Published: 15 June 2026
0 citations · 0 en 2025–2026
An in silico approach to the mechanical design of meta-materials for adipose tissue engineering
Emanuele Luigi Carniel; Chiara Giulia Fontanella; Maria Vittoria Mascolini; Sofia Pettenuzzo; Ilaria Toniolo; Alice Berardo
Research article, Volume 11, Issue 10e43430, Published: May 2025
2 citations · 2 en 2025–2026
Targeted immunotherapy rescues pulmonary fibrosis by reducing activated fibroblasts and regulating alveolar cell profile
Jing Yan; Song-Yu Wang; Qi Su; Min-Wen Zou; Zi-Yue Zhou; Jian Shou; Yunlong Huo
Nat Commun 16, 3748 (2025), Published: 21 April 2025
63 citations · 63 en 2025–2026
Electromagnetic interference shielding in soft, lightweight, and flexible conducting polymer-based sponges
Biporjoy Sarkar; Floriane Miquet-Westphal; Jiaxin Fan; Gayaneh Petrossian; Fabio Cicoira
IOP Publishing Ltd, Biporjoy Sarkar et al 2025 Flex. Print. Electron. 10 025002, Published: 3 April 2025
2 citations · 2 en 2025–2026
Mechanical characterization of an origami-inspired super deformable metamaterial with high tunability for tissue engineering
M.A. Bagheri; C.E. Aubin; M.L. Nault; I. Villemure
Materials & Design, Volume 251, 2025, 113701, ISSN 0264-1275, Published: March 2025
10 citations · 10 en 2025–2026
Design and characterization of an optical phantom for mesoscopic multimodal fluorescence lifetime imaging and optical coherence elastography
Luis Chavez; Shan Gao; Vikas Pandey; Nanxue Yuan; Saif Ragab; Jiayue Li; Matt S. Hepburn; Percy Smith; Caroline Edelheit; David T. Corr; Brendan F. Kennedy; Xavier Intes
Biomedical Optics Express Vol. 16, Issue 3, pp. 1006-1024 (2025), Published: February 12, 2025
3 citations · 2 en 2025–2026
Colloid-Forming Prodrug-Hydrogel Composite Prolongs Lower Intraocular Pressure in Rodent Eyes after Subconjunctival Injection
Mickael Dang; Kai V. Slaughter; Hong Cui; Christopher Jiang; Lisa Zhou; David J. Matthew; Jeremy M. Sivak; Molly S. Shoichet
Adv. Mater. 2025, 2419306, First published: 06 January 2025
16 citations · 16 en 2025–2026
Articular cartilage optical properties vary with tissue depth and integrity
Publications of the University of Eastern Finland Dissertations in Science, Forestry and Technology No 92, 2025
0 citations · 0 en 2025–2026
3D-bioprinted tri-layered cellulose/collagen-based drug-eluting fillers for the treatment of deep tunneling wounds
Mano Govindharaj; Noura Al Hashimi; Soja S. Soman; Jiarui Zhou; Safeeya AlAwadhi; Sanjairaj Vijayavenkataraman
Bio-des. Manuf. (2024), Published: 22 October 2024
4 citations · 4 en 2025–2026
Age and Gender Related Variability in the Strength of Auricular Cartilage in Living Humans
Fuat Buyuklu; Mert Poyraz Cakmak; Berk Ayaz Cakmak; Elif Durukan; Evren Hizal
Aesth Plast Surg (2024)., Published: 18 November 2024
3 citations · 3 en 2025–2026
An Integrated Approach to Control the Penetration Depth of 3D-Printed Hollow Microneedles
Kendall Marie Defelippi; Allyson Yuuka Saumei Kwong; Julia Rose Appleget; Rana Altay; Maya Bree Matheny; Mary Margaret Dubus; Lily Marie Eribes; Maryam Mobed-Miremadi
Appl. Mech. 2024, 5, 233-259, Published: 22 March 2024
5 citations · 4 en 2025–2026
High hydrostatic pressure treatment for advanced tissue grafts in reconstructive head and neck surgery
Friederike Kalle; Valentin Paul Stadler; Julia Kristin Brach; Vivica Freiin Grote; Christopher Pohl; Karoline Schulz; Michael Seidenstuecker; Anika Jonitz‐Heincke; Rainer Bader; Robert Mlynski; Daniel Strüder
Epub ahead of print. PMID: 39295278, Published: 18Sep2024
5 citations · 5 en 2025–2026
Mechanical characterization of soft biomaterials: which time and spatial scale to choose?
Ekaterina S. Krivega; Svetlana L. Kotova; Peter S. Timashev; Yuri M. Efremov
Soft Matter, 2024, 20, 5095, Received 3rd May 2024, Accepted 11th June 2024
17 citations · 15 en 2025–2026
Multi-Structural Fibril-Reinforced Poro-Hyperelastic (MSFPH) Finite Element Modeling Approach for Advanced Understanding of Articular Cartilage Pathomechanics
University of Louisiana at Lafayette ProQuest Dissertations & Theses, 2024. 30989264, Spring 2024
Optical Measurement of Directional, Regional, and Strain Rate Dependent Mechanical Properties of Human Brain Tissue under Uniaxial Compression
University of Alberta, A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science, Graduation date: Spring 2024
Photon-counting in dual-contrast-enhanced computed tomography: a proof-of-concept quantitative biomechanical assessment of articular cartilage
Petri Paakkari; Satu I. Inkinen; Ali Mohammadi; Miika T. Nieminen; Anisha Joenathan; Mark W. Grinstaff; Juha Töyräs; Janne T. A. Mäkelä; Juuso T. J. Honkanen
Scientific Reports volume 14, Article number: 29956 (2024) Published: 02 December 2024
2 citations · 2 en 2025–2026
Revealing the Dynamic Interplay between Lymphangioleiomyomatosis Cells and T Cells in LAM Progression
A thesis submitted in conformity with the requirements for the degree of Doctor of Philosophy Institute of Biomedical Engineering University of Toronto © Copyright by Chang (Amber) Xue 2024
0 citations · 0 en 2025–2026
T-Cell Differentiation from Hematopoietic Progenitor Cells Using 3D Thymic-like Hydrogels
Asel Primbetova; Han Hsuan Hsu; Alexander Baker; Ross Jones; Carla Zimmerman; Molly Shoichet; Peter W. Zandstra
GEN Biotechnology, Vol. 3, No. 3, Published Online: 22 June 2024
4 citations · 4 en 2025–2026
The role of pore size and mechanical properties on the accumulation, retention and distribution of F98 glioblastoma cells in macroporous hydrogels
Lisa Delattre; Sahar Naasri; Angela Giraldo Solano; Hélène Therriault; Simon Bergeron-Fortier; Vaiana Moreau; Benoît Liberelle; Gregory De Crescenzo; Marc-Antoine Lauzon; Nathalie Faucheux; Benoit Paquette; Nick Virgilio
Biomed. Mater, PMID: 38870993, Published: 26Jun2024
4 citations · 4 en 2025–2026
Ultrasound Triggered Gelation to Treat Discogenic Lower Back Pain
Veerle Brans; Anna Constantinou; Luca Bau; Constantin Coussios; Molly Stevens; Michael Gray; Matthew Kibble; Nicolas Newell
University of Oxford, Imperial College London, Published: 29 November 2024
0 citations · 0 en 2025–2026
On the fractional transversely isotropic functionally graded nature of soft biological tissues: Application to the meniscal tissue
Sachin Gunda; Sundararajan Natarajan; Olga Barrera
Journal of the Mechanical Behavior of Biomedical Materials, Volume 143, 2023, 105855, ISSN 1751-6161, Published: 6 May 2023
6 citations · 3 en 2025–2026
A novel workflow to fabricate a patient-specific 3D printed accommodative foot orthosis with personalized latticed metamaterial
Yuri F Hudak; Jing-Sheng Li; Scott Cullum; Brian M Strzelecki; Chris Richburg; G Eli Kaufman; Daniel Abrahamson; Jeffrey T. Heckman; Beth Ripley; Scott Telfer; William R Ledoux; Brittney C Muir; Patrick M Aubin
Medical Engineering & Physics, Volume 104, 2022, 103802, ISSN 1350-4533, https://doi.org/10.1016/j.medengphy.2022.103802.
53 citations · 33 en 2025–2026
Influence of osteoarthritis on knee biomechanics: characterization of articular cartilage through experimental tests [English translation]
Università degli Studi di Padova. Thesis. Academic year 2022/2023. Repository citation year: 2022. Original abstract: Italian.
The Human Meniscus Behaves as a Functionally Graded Fractional Porous Medium under Confined Compression Conditions
Raphaël Bulle; Gioacchino Alotta; Gregorio Marchiori; Matteo Berni; Nicola F. Lopomo; Stefano Zaffagnini; Stéphane P. A. Bordas; Olga Barrera
Appl. Sci. 2021, 11, 9405. https://doi.org/10.3390/app11209405
18 citations · 3 en 2025–2026
A comprehensive testing protocol for macro-scale mechanical characterization of knee articular cartilage with documented experimental repeatability
Snehal Chokhandre; Ahmet Erdemir
Journal of the Mechanical Behavior of Biomedical Materials (2020), doi: https://doi.org/10.1016/j.jmbbm.2020.104025.
20 citations · 7 en 2025–2026
Three-Dimensional (3D) Printed Microneedles for Microencapsulated Cell Extrusion
Chantell Farias; Roman Lyman; Cecilia Hemingway; Huong Chau; Anne Mahacek; Evangelia Bouzos; Maryam Mobed-Miremadi
Bioengineering (Basel, Switzerland). 2018;5(3):E59.
84 citations · 14 en 2025–2026
Combined Mechanical Characterizations Increases Sensitivity in the Assessment of Human Cartilage Degeneration
Sim S; Hadjab I; Chevrolat L-A; Masse M; Tong AL; Lavigne P; Garon M; Quenneville E; Buschmann MD
Accepted for a podium presentation at ORS 2017
Effect of Multiple Confined Compression/Stress Relaxation Cycles on Cross-linked Alginate Pore Size
Kolar Venkat S; Risa EL; Antell B; Mobed-Miremadi M
Biomedical Engineering Society 2017 (BMES) Phoenix - Arizona
0 citations · 0 en 2025–2026
Characterization of tissue engineered cartilage products - Recent developments in advanced therapy
Justinas Mačiulaitis; Sima Rekštytė; Arvydas Ūsas; Virginija Jankauskaitė; Rimtautas Gudas; Mangirdas Malinauskas; Romaldas Mačiulaitis
Pharmacological Research 113 (2016) 823–832
10 citations · 1 en 2025–2026
Comparison of natural crosslinking agents for the stabilization of xenogenic articular cartilage
Amanda Pinheiro; Avery Cooley; Jun Liao; Rajkumar Prabhu; Steven Elder
J Orthop Res. 2016 Jun;34(6):1037-46. doi: 10.1002/jor.23121. Epub 2015 Dec 18.
81 citations · 10 en 2025–2026
Development of a Sequence of Mechanical Tests for Articular Cartilage at a Single Location
Sim S; Chartrand A; Lavallee AP; Tessier J; Garon M; Quenneville E; Buschmann MD
Orthopeadic Research Society Annual Meeting in Orlando, 2016
Mechanical characterization of matrix-induced autologous chondrocyte implantation (MACI®) grafts in an equine model at 53 weeks
Darvin J. Griffin; Edward D. Bonnevie; Devin J. Lachowsky; James C.A. Hart; Holly D. Sparks; Nance Moran; Gloria Matthews; Alan J. Nixon; Itai Cohen; Lawrence J. Bonassar
Journal of biomechanics, 48(10), 1944-1949. (2015)
59 citations · 8 en 2025–2026
Calcium regulates cyclic compression-induced early changes in chondrocytes during in vitro cartilage tissue formation
Igal Raizman; J.N. Amritha De Croos; Robert Pilliar; Rita A. Kandel
Cell Calcium. 2010;48(4):232–242.
44 citations · 2 en 2025–2026
Tissue engineering cartilage for focal defects
Mississippi State University. M.S. thesis, Biomedical Engineering. 2010-08.
0 citations · 0 en 2025–2026
Matrix accumulation by articular chondrocytes during mechanical stimulation is influenced by integrin‐mediated cell spreading
Caroline Spiteri; Igal Raizman; Robert M. Pilliar; Rita A. Kandel
Journal of Biomedical Materials Research Part A. 2010.
19 citations · 2 en 2025–2026
Improved bioengineered cartilage tissue formation following cyclic compression is dependent on upregulation of MT1‐MMP
J. N. Amrith De Croos; Peter J. Roughley; Rita A. Kandel
Journal of Orthopaedic Research. 2010;28(7):921-927. DOI:10.1002/jor.21064. First online 2010-01-07. Methods provenance:earlier ORS2009poster1051;distinctive MT1MMPsiRNA/MMP13 result correspondence. Not official reprint;final journal methods not independently read.
7 citations · 1 en 2025–2026
Characterization of intervertebral disc mechanical properties and their relationships with quantitative magnetic resonance imaging
Polytechnique Montréal. MASc. 2010
Characterization of the mechanical properties of intervertebral discs and their relationships with quantitative magnetic resonance imaging [English translation]
École Polytechnique de Montréal, Université de Montréal. Master of Applied Science thesis. December 2010.
Articular cartilage subpopulations respond differently to cyclic compression in vitro
Igal Raizman; J.N. Amritha De Croos; Jean-Philippe St-Pierre; Robert M. Pilliar; Rita A. Kandel
Tissue Engineering Part A. 2009;15(12):3789–3798.
12 citations · 1 en 2025–2026
Calcium Regulates Cyclic Compression-Induced Early Changes In Chondrocytes During In Vitro Tissue Formation
Master of Science thesis, University of Toronto, 2009.
Characterization of a Biodegradable Electrospun Polyurethane Nanofiber Scaffold Suitable for Annulus Fibrosus Tissue Engineering
University of Toronto. Master of Applied Science and Engineering thesis. 2009.
0 citations · 0 en 2025–2026
Mechanical Forces Regulate Cartilage Tissue Formation by Chondrocytes Via Integrin-mediated Cell Spreading
Thesis, University of Toronto, 2009.
0 citations · 0 en 2025–2026
Membrane type-1 matrix metalloproteinase is induced following cyclic compression of in vitro grown bovine chondrocytes
J.N.A. De Croos; B. Jang; S.S. Dhaliwal; M.D. Grynpas; R.M. Pilliar; R.A. Kandel
Osteoarthritis and Cartilage. 2007;15(11):1301-1310.
20 citations · 0 en 2025–2026
FAQ
Qu'est-ce que le module d'Young E?+
Module de laboratoire — Compression non confinée de disques d’hydrogel
Qu'est-ce que la poroelasticité?+
Mach-1 Analysis – Modèle poroélastique en compression non-confinée – Paramètres
Mach-1 Analysis – Modèle poroélastique en compression confinée – Paramètres
Mach-1 Analysis – Modèle poroélastique en compression confinée – Exemple
Mach-1 Analysis – Modèle poroélastique en compression non-confinée – Cartilage
Mach-1 Analysis – Modèle poroélastique en compression non-confinée – Exemple
LAB MODULE – Torsion of Disk-Shaped Samples – Student Version
Qu'est-ce que la contrainte de cisaillement?+
Module de laboratoire — Torsion de l’os
Module de laboratoire — Torsion d’échantillons en forme de disque
LAB MODULE – Torsion of Bone – Student Version
LAB MODULE – Torsion of Disk-Shaped Samples – Student Version
Qu'est-ce que le module de cisaillement?+
Module de laboratoire — Torsion de l’os
Module de laboratoire — Torsion d’échantillons en forme de disque
LAB MODULE – Torsion of Bone – Student Version
LAB MODULE – Torsion of Disk-Shaped Samples – Student Version
Comment fonctionne le modèle poroélastique en compression confinée "Poroelastic Model in Confined Compression"?+
This model is well adapted for the mechanical characterization of samples containing a liquid fraction and a solid matrix, for example: cartilage or gel samples. A user license is required in order to obtain the results of the poroelastic model in confined compression (Software Add-On, contact Biomomentum to obtain your license).
Mechanical properties can be obtained from the stress relaxation curves obtained under confined compression such as the aggregate modulus (HA) and the hydraulic permeability (k). The aggregate modulus is a measure of stiffness of the sample at equilibrium while the hydraulic permeability is the ability of the fluid to flow through the cartilage matrix.
For example, (Figure 2) shows parameters used for the “Stress Relaxation” function in a confined compression testing protocol on human cartilage disks. Corresponding results are shown in (Figure 1).
Mach-1 Analysis – Modèle poroélastique en compression confinée – Paramètres
Mach-1 Analysis – Modèle poroélastique en compression confinée – Exemple
Qu'est-ce que le module aggrégat?+
Quelles sont les caractéristiques de la fonction de relaxation de contrainte (Stress Relaxation)?+
During a “Stress Relaxation” test, a ramp is executed at velocity V and amplitude A, followed by a relaxation (plateau) in which a constant position is held during a time period specified by the user. Several identical ramp-relaxation cycles may be executed one after another.
Parameters:
STAGE AXIS - On multi-axis systems, the user must specify which axis will perform the “Stress Relaxation”.
LOAD CELL AXIS - When using a multiple-axis load cell, the measurement axis can be selected.
Note: The selected “Load Cell Axis” must be consistent with the “Stage Axis”. For example, if the “Vertical (z)” stage axis is selected, the “Load Cell Axis” must have a component along the vertical axis, such as the load along the z axis (the force along z axis or the torque along the x or y axis uses a multiple-axis load cell) in order to eventually attain the “Stop based on” criteria. FAILURE TO MATCH THE “LOAD CELL AXIS” TO THE “STAGE AXIS” CAN RESULT IN DAMAGING OF THE LOAD CELL.
RAMP AMPLITUDE - This is the amplitude that the stage will reach. Full stage range is allowed. A positive amplitude will move the vertical stage down (compression), the horizontal stage, right, and the rotation stage, clockwise. Enter a negative amplitude for opposite directions.
RAMP VELOCITY - This is the velocity at which the stage executes the ramp. Refer to the specifications of your Mach-1™ model to learn of the velocity range allowed. In Mach-1 Motion, the speed is always specified in absolute value terms.
NUMBER OF RAMPS - This is the number of identical displacement/hold cycles to be executed.
STOP BASED ON - There are two ways of determining the end of each relaxation profile (ramp/hold cycle) before applying the next ramp: “Fixed Relaxation Time” and “Relaxation Rate”.
“Fixed Relaxation Time” specifies the duration of each relaxation.
“Relaxation Rate” dynamically monitors the load vs. time slope and ends the relaxation when this slope is less than the “Relaxation Rate per min.” specified by the user. The period over which the slope is calculated is specified by the “Time for Measurement of the Slope, s”. Although a longer period will result in a more accurate slope, keep in mind that the specified relaxation rate can be attained more quickly than the time for measurement of the slope.
FIXED RELAXATION TIME - Specify the relaxation duration when “Fixed Relaxation Time” is selected in the “Stop based on” menu.
RELAXATION RATE PER MIN - Specify the relaxation rate when “Relaxation Rate” is selected from the “Stop based on” menu. The units are grams per minute or newtons per minute, depending on the load measurement units of the selected load cell.
TIME FOR MEASUREMENT OF THE SLOPE - Specify the period over which the relaxation slope is calculated when “Relaxation Rate” is selected in the “Stop based on” menu.
Mach-1 Motion – Fenêtre de la fonction Stress Relaxation
Mach-1 Motion-Stress Relaxation-Position typique en fonction de la courbe de tem
Qu'est-ce que la viscoélasticité?+
LAB MODULE – Torsion of Disk-Shaped Samples – Student Version
Qu'est-ce que le taux de déformation?+
Qu'est-ce que l'élasticité?+
Module de laboratoire — Torsion de l’os
LAB MODULE – Unconfined Compression of Hydrogel Disks – Student Version










