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Indenter, Spherical (D=6.35 mm)

Indenter, Spherical (D=6.35 mm)

MA679

Attached under the load cell it is used to indent a sample

SKU: MA679 Categories: ,

This spherical indenter is used in a wide variety of test configuration.

  • This accessory has been designed to facilitate cleaning and desinfection.
  • This part has a robust design and will keep its integrity for years
  • Designed to be used in contact with physiological saline solution
  • Easy to assemble and mount on the tester
  • A knurling facilitates assembly
Material

Stainless Steel 316L
Diameter

6.35 mm
Upper Attachment

1/4-28 male thread

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Documents and resources (2)

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Test configurations (6)

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Frontiers in Bioengineering and Biotechnology. 2026;14:1973631. Published 5 November 2026. DOI: 10.3389/fbioe.2026.1973631

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March 12, 2026 · Journal Articles

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February 10, 2026 · Journal Articles

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January 18, 2026 · Journal Articles

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January 12, 2026 · Journal Articles

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December 2025 · Journal Articles

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August 22, 2025 · Journal Articles

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August 21, 2025 · Journal Articles

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August 6, 2025 · Journal Articles

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July 24, 2025 · Journal Articles

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June 4, 2025 · Journal Articles

Impact of applying traction in indentation tests for estimating axial compressive parameters for computational modeling of sutured meniscal horns

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May 21, 2025 · Journal Articles

Relationships between human patellar tendon and tibial cartilage viscoelastic properties in osteoarthritic knees: an exploratory investigation

Adam Kositsky; Awuniji Linus; Lauri Stenroth; Ervin Nippolainen; Heikki Kröger; Juha Töyräs; Janne T.A. Mäkelä; Mimmi K. Liukkonen; Petri Tanska; Isaac O. Afara; Mika E. Mononen; Rami K. Korhonen

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May 9, 2025 · Journal Articles

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May 2025 · Thesis

3D Bioprinting of Perfusable Cardiac Patches to Treat Myocardial Infarction

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Protocol for 3D bioprinting of a 3D in vitro model of neuroblastoma

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6 citations · 6 in 2025–2026

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April 2025 · Meeting abstracts & presentations

Regional Articular Cartilage Deterioration Following Knee Injury in an Osteoarthritis In Vivo Rat Model

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Osteoarthritis and Cartilage 33, Supplement, S335, April 2025. OARSI abstract 468. Complete original published English abstract; same-title author poster from the internal literature server supports instrument attribution. The published abstract reports 1% glutaraldehyde whereas the poster reports 0.1%; each source retained verbatim, no silent correction.

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January 31, 2025 · Journal Articles

The Relationship Between the Optical Properties of Articular Cartilage and the Biomechanical Parameters of the Tissue

Iman Kafian‐Attari; Mohammad Ebrahimi; Ervin Nippolainen; Arash Mirhashemi; Petri Paakkari; Florian Bergmann; Florian Foschum; Alwin Kienle; Juha Töyräs; Isaac Afara

J. Biophotonics e202400460, First published: 31 January 2025

1 citation · 1 in 2025–2026

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2025 · Thesis

Region Partitioning of Articular Cartilage to Approximate Tissue Inhomogeneity with Applications in Knee Joint Modeling

Erfan Hamsayeh Abbasi Niasar

University of Calgary. PhD thesis, June 2025. Original abstract: English. Chapter 4 reanalyses previously acquired porcine Arthro-BST and Mach-1 data; this is not counted as an independent new experiment.

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October 18, 2024 · Journal Articles

Structure-function of cartilage in osteoarthritis: An ex-vivo correlation analysis between its structural, viscoelastic and frictional properties

Luisa de Roy; Graciosa Quelhas Teixeira; Jonas Schwer; Matthias Sukopp; Martin Faschingbauer; Anita Ignatius; Andreas Martin Seitz

Acta Biomaterialia 190 (2024), 293–302. Available online 18 October 2024. Original publisher PDF, CC BY, deposited with the German National Library. Original English abstract copied in full. The user confirmed local-normal 3D indentation. Confined compression used a Zwick Z10 and friction used a separate tribometer.

17 citations · 17 in 2025–2026

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October 2024 · Meeting abstracts & presentations

Mechanical characterization of the thymic niche for bio-mimetic approaches

F. Fontana; L. Cacopardo; I. Valente; N. Guazzelli; G. Paties Montagner; M. Ciardelli; F. Pratesi; A. Corti; A. Ahluwalia

XIII Annual Meeting of the Italian Chapter of the European Society of Biomechanics, Pescara, 3–4 October 2024. Official Book of Abstracts PDF p.26: exact title, nine authors, full scientific abstract body (Introduction, Methods, Results, Discussion) and apparatus visually verified. Original body copied; figure caption, references and funding statement remain in archived source, no image embedded in abstract. Custom Material denotes native bovine thymus. Found while researching malformed C0199, but identity with that export fragment is NOT established; this is an additional independently verified discovery and C0199 stays pending. Bulk compression and shear are future work, so not classified as performed. No 3D normal inference from V500CSS or mapping.

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February 16, 2024 · Thesis

A multidisciplinary experimental framework addressing the relationship between the mechanical behaviour and the structure of the knee articular cartilage

Matteo Berni

Università degli Studi di Brescia, PhD in Technology for Health. Repository citation date: 16 February 2024; not asserted as a defence date. English original repository abstract copied in full. PDF identity checked against thesis cover. Original methods pp.48–50 and Appendix A p.57 establish local surface orientation detection and indentation along the local normal. Reprinted papers are thesis chapters, not additional independent experiments.

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2024 · Meeting abstracts & presentations

Changes in Axial Compression Parameters of the Sutured Human Meniscal Horn Subjected to Axial Compression and Circumferential Traction: Experimental–Computational Analysis [English translation]

Alejandro Peña-Trabalon; Maria Prado-Novoa; Luisa de Roy; Andreas M. Seitz; Salvador Moreno-Vegas; M. Belen Estebanez Campos; Ana Perez-Blanca

XVI Congreso Iberoamericano de Ingeniería Mecánica, Concepción, Chile, 22–24 October 2024. Full conference paper, 11 pages. English title is an identified translation of the original Spanish title. Original English abstract. Alternate-title deposit: https://hdl.handle.net/10630/40185. Related journal article in 2025 is a distinct publication.

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2024 · Journal Articles

Comparison of site-specific tensile, compressive, and friction properties of human tibiofemoral joint cartilage and their relationship to degeneration

Aapo Ristaniemi; Juuso Tuppurainen; Jiri Jäntti; Ervin Nippolainen; Isaac O. Afara; Mika E. Mononen; Rami K. Korhonen; Janne T.A. Mäkelä

Journal of Biomechanics, Volume 177, 2024, 112386, ISSN 0021-9290, Available online 28 October 2024

7 citations · 7 in 2025–2026

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2024 · Thesis

Computed tomography imaging and functional in silico modelling of cartilage, bone and tissue engineered cartilage constructs

Heta Orava

University of Eastern Finland, doctoral dissertation 2024, Dissertations in Science, Forestry and Technology 42, ISBN 978-952-61-5202-8. Exact official thesis cover and complete original English abstract, PDF pp.7–9, visually verified. Study II samples on p.53 are human cadaveric knees; Mach-1 stress-relaxation indentation on p.55. Study III hydrogel unconfined compression used Instron 5567, and study I rabbit bone was computational modelling; neither is assigned to Mach-1. The word perpendicular and a mapping protocol alone do not establish the local-normal 3D function. Related thesis chapters/papers are not counted as independent experiments.

0 citations · 0 in 2025–2026

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2024 · Meeting abstracts & presentations

Improved Computational Modeling of the Mechanical Behavior of Sutured Human Meniscal Tissue under Combined Loading [English translation]

Alejandro Peña-Trabalon; Maria Prado-Novoa; Salvador Moreno-Vegas; M. Belen Estebanez Campos; Ana Perez-Blanca

XIII Congreso del Capítulo Español de la Sociedad Europea de Biomecánica (ESB), Pamplona, 28–29 October 2024. Original abstract: Spanish (español). English title is an identified translation. Separate communication from the 2024 CIBIM full paper and 2025 journal article.

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2024 · Journal Articles

In situ assembly of an injectable cardiac stimulator

Umut Aydemir; Abdelrazek H. Mousa; Cedric Dicko; Xenofon Strakosas; Muhammad Anwar Shameem; Karin Hellman; Amit Singh Yadav; Peter Ekström; Damien Hughes; Fredrik Ek; Magnus Berggren; Anders Arner; Martin Hjort; Roger Olsson

Nat Commun 15, 6774 (2024), Published: 08 August 2024

11 citations · 10 in 2025–2026

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2024 · Journal Articles

Photon-counting in dual-contrast-enhanced computed tomography: a proof-of-concept quantitative biomechanical assessment of articular cartilage

Petri Paakkari; Satu I. Inkinen; Ali Mohammadi; Miika T. Nieminen; Anisha Joenathan; Mark W. Grinstaff; Juha Töyräs; Janne T. A. Mäkelä; Juuso T. J. Honkanen

Scientific Reports volume 14, Article number: 29956 (2024) Published: 02 December 2024

2 citations · 2 in 2025–2026

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2024 · Journal Articles

Protocol for 3D bioprinting of nanoparticle-laden hydrogels to enhance antibacterial and imaging properties

Mehdi Salar Amoli; Linqi Jin; Sarah Rezapourdamanab; Maher Saadeh; Yamini Singh; Liqun Ning; Boeun Hwang; Martin L. Tomov; Christopher N. LaRock; Morteza Mahmoudi; Holly Bauser-Heaton; Vahid Serpooshan

STAR Protocols, Volume 5, Issue 4, 2024, 103393, ISSN 2666-1667, 20 December 2024

0 citations · 0 in 2025–2026

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2024 · Thesis

Relationships between Meniscal Extrusion and the Biomechanical Properties of Meniscus and Tibial Articular Cartilage in Healthy Individuals and Patients with Osteoarthritis [English translation]

Sophie Dittberner

Zusammenhänge zwischen Meniskusextrusion und biomechanischen Eigenschaften von Meniskus und tibialem Gelenkknorpel bei Gesunden und Arthrosepatienten. Thesis, 2024. DOI: 10.18725/oparu-53282 Original German title: Zusammenhänge zwischen Meniskusextrusion und biomechanischen Eigenschaften von Meniskus und tibialem Gelenkknorpel bei Gesunden und Arthrosepatienten. The displayed English title is an identified translation. The complete original German summary is retained.

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2024 · Journal Articles

Scar matrix drives Piezo1 mediated stromal inflammation leading to placenta accreta spectrum

Du Wenqiang; Ashkan Novin; Yamin Liu; Junaid Afzal; Yasir Suhail; Shaofei Liu; Nicole R. Gavin; Jennifer R. Jorgensen; Christopher M. Morosky; Reinaldo Figueroa; Tannin A. Schmidt; Melinda Sanders; Molly A. Brewer; Kshitiz

Nat Commun 15, 8379 (2024), Published: 27 September 2024

27 citations · 27 in 2025–2026

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2024 · Journal Articles

Site-specific elastic and viscoelastic biomechanical properties of healthy and osteoarthritic human knee joint articular cartilage

Awuniji Linus; Petri Tanska; Ervin Nippolainen; Virpi Tiitu; Juha Töyras; Rami K. Korhonen; Isaac O. Afara; Mika E. Mononen

Journal of Biomechanics, Volume 169, 2024, 112135, ISSN 0021-9290, Published: May2024

13 citations · 13 in 2025–2026

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2023 · Thesis

Biomechanical and Biochemical Characterization of Menisci and Articular Cartilage in Degenerated Knees [English translation]

Felix Osthaus

Biomechanische und biochemische Charakterisierung von Menisken und Gelenkknorpel degenerierter Knie. Thesis, 2023. DOI: 10.18725/oparu-49387 Original German title: Biomechanische und biochemische Charakterisierung von Menisken und Gelenkknorpel degenerierter Knie. The displayed English title is an identified translation. The complete original German summary is retained.

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2023 · Thesis

Biomechanics and Mechanobiology of Impacted Cartilage: In-Vitro and In-Vivo Studies

Hessam Noori-Dokht

Purdue University. PhD dissertation, August 2023. Original abstract: English. Two Scholar notices C0207 and C1080 represent this same dissertation: exact title, same author with reversed compound surname, same university. Mach-1 methods concern bovine cartilage; rabbit impact studies used a separate drop tower.

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2023 · Journal Articles

Correlations between elastic modulus and ultrashort echo time (UTE) adiabatic T1P relaxation time (UTE-Adiab-T1P) in Achilles tendons and entheses

Saeed Jerban; Amir Masoud Afsahi; Yajun Ma; Dina Moazamian; Sheronda Statum; Alecio F. Lombardi; Lena Kakos; Erik Dorthe; Daryll Dlima; Jiang Du; Christine B. Chung; Eric Y. Chang

Journal of Biomechanics, Volume 160, 2023, 111825, ISSN 0021-9290, Published: November 2023

6 citations · 2 in 2025–2026

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2023 · Journal Articles

FLIM imaging revealed spontaneous osteogenic differentiation of stem cells on gradient pore size tissue-engineered constructs

Svetlana Rodimova; Artem Mozherov; Vadim Elagin; Maria Karabut; Ilya Shchechkin; Dmitry Kozlov; Dmitry Krylov; Alena Gavrina; Vladislav Kaplin; Evgenii Epifanov; Nikita Minaev; Ksenia Bardakova; Anna Solovieva; Peter Timashev; Elena Zagaynova; Daria Kuznetsova

Stem Cell Research & Therapy volume 14, Article number: 81 (2023), Published: 12 April 2023

7 citations · 6 in 2025–2026

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2023 · Journal Articles

Load-induced fluid pressurisation in hydrogel systems before and after reinforcement by melt-electrowritten fibrous meshes

Eng Kuan Moo; Mohammadhossein Ebrahimi; Andrei Hrynevich; Mylène de Ruijter; Miguel Castilho; Jos Malda; Rami K. Korhonen

Journal of the Mechanical Behavior of Biomedical Materials, Volume 143, 2023, 105941, ISSN 1751-6161, Published:

10 citations · 7 in 2025–2026

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2023 · Journal Articles

Mechanical Behaviour of Plantar Adipose Tissue: From Experimental Tests to Constitutive Analysis

Sofia Pettenuzzo; Elisa Belluzzi; Assunta Pozzuoli; Veronica Macchi; Andrea Porzionato; Rafael Boscolo-Berto; Pietro Ruggieri; Alice Berardo; Emanuele Carniel; Chiara Fontanella

BibTeX, EndNote, RIS, Bioengineering 2024, 11, 42, Published: 31 December 2023

9 citations · 8 in 2025–2026

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2023 · Journal Articles

Visible and Near-Infrared Spectroscopy Enables Differentiation of Normal and Early Osteoarthritic Human Knee Joint Articular Cartilage

Awuniji Linus; Petri Tanska; Jaakko K. Sarin; Ervin Nippolainen; Virpi Tiitu; Janne.T. A. Mäkelä; Juha Töyräs; Rami K. Korhonen; Mika E. Mononen; Isaac O. Afara

Annals of Biomedical Engineering, Published: 18 June 2023

21 citations · 13 in 2025–2026

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June 2022 · Meeting abstracts & presentations

Biomechanics of articular cartilage degraded with MMP-1 and MMP-9 mimicking early-stage knee OA

Allison Mixon; Tanvir R. Faisal

M2D2022, 9th International Conference on Mechanics and Materials in Design, Funchal, 26–30 June 2022, pp.893–894, paper 18265. Exact proceedings PDF text read through the Web PDF reader: title, two authors, full original ABSTRACT and methods on both pages. Local download currently returns HTTP 500; PDF optional, not falsely marked archived. This is a distinct conference communication from the three-author JMBBM 2022 article already in SQL; no methods transferred from that article. The source explicitly names Mach-1 v500c and juvenile bovine cartilage. Abstract transcribed in full without editorial paraphrasing; figure omitted.

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January 6, 2022 · Journal Articles

Generation of double-layered equine mesenchymal stromal cell-derived osteochondral constructs

Cristóbal López-Jiménez; Sarah I.M. Lepage; Loraine L.Y. Chiu; Stephen D. Waldman; Matthew K. Vickaryous; Rita A. Kandel; Thomas G. Koch

Journal Articles, 2022. DOI: 10.1016/j.jcjp.2021.100036

1 citation · 0 in 2025–2026

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2022 · Journal Articles

3D bioprinting of nanoparticle-laden hydrogel scaffolds with enhanced antibacterial and imaging properties

Andrea S. Theus; Liqun Ning; Gabriella Kabboul; Boeun Hwang; Martin L. Tomov; Christopher N. LaRock; Holly Bauser-Heaton; Morteza Mahmoudi; Vahid Serpooshan

ISCIENCE (2022), doi: https:// doi.org/10.1016/j.isci.2022.104947, Accepted Date: 11 August 2022

34 citations · 15 in 2025–2026

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2022 · Journal Articles

A defined road to tracheal reconstruction: laser structuring and cell support for rapid clinic translation

Alexey Fayzullin; Georgiy Vladimirov; Anastasia Kuryanova; Elvira Gafarova; Sergei Tkachev; Nastasia Kosheleva; Elena Istranova; Leonid Istranov; Yuri Efremov; Ivan Novikov; Polina Bikmulina; Kirill Puzakov; Pavel Petrov; Ivan Vyazankin; Andrey Nedorubov; Tatyana Khlebnikova; Valentina Kapustina; Pavel Trubnikov; Nikita Minaev; Aleksandr Kurkov; Valery Royuk; Vasily Mikhailov; Dmitriy Parshin; Anna Solovieva; Marina Lipina; Alexey Lychagin; Peter Timashev; Andrey Svistunov; Victor Fomin; Anastasia Shpichka

BMC, Stem Cell Research & Therapy volume 13, Article number: 317 (2022), Published: 16 July 2022

13 citations · 4 in 2025–2026

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2022 · Journal Articles

A novel workflow to fabricate a patient-specific 3D printed accommodative foot orthosis with personalized latticed metamaterial

Yuri F Hudak; Jing-Sheng Li; Scott Cullum; Brian M Strzelecki; Chris Richburg; G Eli Kaufman; Daniel Abrahamson; Jeffrey T. Heckman; Beth Ripley; Scott Telfer; William R Ledoux; Brittney C Muir; Patrick M Aubin

Medical Engineering & Physics, Volume 104, 2022, 103802, ISSN 1350-4533, https://doi.org/10.1016/j.medengphy.2022.103802.

53 citations · 33 in 2025–2026

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2022 · Preprints

Cartilage-penetrating hyaluronic acid hydrogel preserves tissue content and reduces chondrocyte catabolism

Michael A. Kowalski; Lorenzo M. Fernandes; Kyle E. Hammond; Sameh Labib; Hicham Drissi; Jay M. Patel

bioRxiv preprint doi: https://doi.org/10.1101/2022.05.17.492335; this version posted May 19, 2022

23 citations · 11 in 2025–2026

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2022 · Journal Articles

Fabrication of Curli Fiber-PEDOT:PSS Biomaterials with Tunable Self-Healing, Mechanical, and Electrical Properties

Catrina Huyer; Daniel Modafferi; Masoud Aminzare; Juliana Ferraro; Zahra Abdali; Sophia Roy; Dalia Jane Saldanha; Saadia Wasim; Johan Alberti; Shurui Feng; Fabio Cicoira; Noémie-Manuelle Dorval Courchesne

ACS Biomater. Sci. Eng. 2022, XXXX, XXX, XXX-XXX, Publication Date: June 10, 2022

16 citations · 7 in 2025–2026

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2022 · Journal Articles

Grading cartilage damage with diffuse reflectance spectroscopy: optical markers and mechanical properties

Nataliya R. Rovnyagina; Gleb S. Budylin; Pavel V. Dyakonov; Yuri M. Efremov; Marina M. Lipina; Yuliya R. Goncharuk; Emirkhan E. Murdalov; David A. Pogosyan; Denis A. Davydov; Alexander A. Korneev; Natalia B. Serejnikova; Karen A. Mikaelyan; Stanislav A. Evlashin; Vladimir A. Lazarev; Alexey V. Lychagin; Peter S. Timashev; Evgeny A. Shirshin

Wiley Online Library, Journal of biophotonics, published: 06 September 2022

9 citations · 3 in 2025–2026

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2022 · Preprints

Methacrylate-Modified Gold Nanoparticles Enable Non-Invasive Monitoring of Photocrosslinked Hydrogel Scaffolds

Lan Li; Carmen J. Gil; Tyler A. Finamore; Connor J. Evans; Martin L. Tomov; Liqun Ning; Andrea Theus; Gabriella Kabboul; Vahid Serpooshan; Ryan K. Roeder

bioRxiv, Preprint, Published: January 28, 2022 doi: https://doi.org/10.1101/2022.01.26.477960

1 citation · 0 in 2025–2026

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2022 · Preprints

Signaling modality within gp130 receptor enhances tissue regeneration

Ruzanna Shkhyan; Candace Flynn; Emma Lamoure; Ben Van Handel; Arijita Sarkar; Jinxiu Li; Jesse York; Nicholas Banks; Robert Van der Horst; Nancy Q. Liu; Siyoung Lee; Paul Bajaj; Kanagasabai Vadivel; Hans I-Chen Harn; Thomas Lozito; Jay R. Lieberman; Cheng-Ming Chuong; Mark S. Hurtig; Denis Evseenko

bioRxiv, Posted January 05, 2022

1 citation · 0 in 2025–2026

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2022 · Journal Articles

Site- and Zone-Dependent Changes in Proteoglycan Content and Biomechanical Properties of Bluntly and Sharply Grooved Equine Articular Cartilage

Ali Mohammadi; Nikae C. R. te Moller; Mohammadhossein Ebrahimi; Saskia Plomp; Harold Brommer; P. René van Weeren; Janne T. A. Mäkelä; Juha Töyräs; Rami K. Korhonen

Ann Biomed Eng. Epub ahead of print. PMID: 35754073., Published: 26 June 2022

8 citations · 5 in 2025–2026

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2022 · Journal Articles

The synthetic artificial stem cell (SASC) Shifting the paradigm of cell therapy in regenerative engineering

Shiv Shah; Caldon Jayson Esdaille; Maumita Bhattacharjee; Ho-Man Kan; Cato T. Laurencin

Proceedings of the National Academy of Sciences Jan 2022, 119 (2) e2116865118; DOI: 10.1073/pnas.2116865118

37 citations · 12 in 2025–2026

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2022 · Journal Articles

TRPV4 activation enhances compressive properties and glycosaminoglycan deposition of equine neocartilage sheets

Cristóbal López-Jiménez; Loraine L.Y. Chiu; Stephen D. Waldman; Farshid Guilak; Thomas G. Koch

Osteoarthritis and Cartilage Open, Volume 4, Issue 2, 2022, 100263, ISSN 2665-9131, Published: June2022

3 citations · 2 in 2025–2026

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October 27, 2021 · Journal Articles

Lightweight and flexible conducting polymer sponges and hydrogels for electromagnetic interference shielding

Biporjoy Sarkar; Xinda Li; Eric Quenneville; Louis-Philippe Carignan; Ke Wu; Fabio Cicoira

Journal of Materials Chemistry C. 2021;9(46):16558–16565. First published 27 October 2021; issue 14 December 2021. DOI: 10.1039/d1tc04008a

35 citations · 11 in 2025–2026

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2021 · Journal Articles

Can UVA-light-activated riboflavin-induced collagen crosslinking be transferred from ophthalmology to spine surgery? A feasibility study on bovine intervertebral disc

Ioannis Vasilikos; Graciosa Q. Teixeira; Andreas Seitz; Julia Nothelfer; Julian Haas; Hans-Joachim Wilke; Boris Mizaikoff; Jürgen Beck; Ulrich Hubbe; Cornelia Neidlinger-Wilke

PLoS ONE 16(6): e0252672. https://doi.org/ 10.1371/journal.pone.0252672

5 citations · 2 in 2025–2026

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2021 · Thesis

Fabrication of Curli-PEDOT:PSS Composites for Bioelectronics

Catrina Huyer

McGill University. Master of Engineering thesis, August 2021. Original abstract: English. Scholar export used the alternative title Fabrication of Protein-polymer Composites for Bioelectronics; the official catalogue links this thesis.

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2021 · Journal Articles

Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes

Frank A. Petrigliano; Nancy Q. Liu; Siyoung Lee; Jade Tassey; Arijita Sarkar; Yucheng Lin; Liangliang Li; Yifan Yu; Dawei Geng; Jiankang Zhang; Ruzanna Shkhyan; Jacob Bogdanov; Ben Van Handel; Gabriel B. Ferguson; Youngjoo Lee; Svenja Hinderer; Kuo-Chang Tseng; Aaron Kavanaugh; J. Gage Crump; April D. Pyle; Katja Schenke-Layland; Fabrizio Billi; Liming Wang; Jay Lieberman; Mark Hurtig; Denis Evseenko

npj Regenerative Medicine. 2021;6(1):77. doi: 10.1038/s41536-021-00187-3

17 citations · 6 in 2025–2026

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2021 · Journal Articles

Machine learning augmented near-infrared spectroscopy: In vivo follow-up of cartilage defects

J.K. Sarin; N.C.R. te Moller; A. Mohammadi; M. Prakash; J. Torniainen; H. Brommer; E. Nippolainen; R. Shaikh; J.T.A. Mäkelä; R.K. Korhonen; P.R. van Weeren; I.O. Afara; J. Töyräs

Osteoarthritis and Cartilage, Volume 29, Issue 3, 2021, Pages 423-432, ISSN 1063-4584, https://doi.org/10.1016/j.joca.2020.12.007.

19 citations · 2 in 2025–2026

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2021 · Journal Articles

Osteoarthritis-Related Degeneration Alters the Biomechanical Properties of Human Menisci Before the Articular Cartilage

Andreas M. Seitz; Felix Osthaus; Jonas Schwer; Daniela Warnecke; Martin Faschingbauer; Mirco Sgroi; Anita Ignatius; Lutz Dürselen

Front Bioeng Biotechnol. 2021 May 6;9:659989. doi: 10.3389/fbioe.2021.659989. PMID: 34026741; PMCID: PMC8134692.

60 citations · 18 in 2025–2026

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2021 · Journal Articles

Structural, compositional, and functional effects of blunt and sharp cartilage damage on the joint: A 9‐month equine groove model study

Nikae C. R. te Moller; Ali Mohammadi; Saskia Plomp; Filipe M. Serra Bragança; Martijn Beukers; Behdad Pouran; Isaac O. Afara; Ervin Nippolainen; Janne T. A. Mäkelä; Rami K. Korhonen; Juha Töyräs; Harold Brommer; P. René van Weeren

J Orthop Res. Accepted Author Manuscript. https://doi.org/10.1002/jor.24971

10 citations · 2 in 2025–2026

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2020 · Journal Articles

Automated Indentation Demonstrates Structural Stiffness of Femoral Articular Cartilage and Temporomandibular Joint Mandibular Condylar Cartilage Is Altered in FgF2KO Mice

Paige S. Woods; Alyssa A. Morin; Po-Jung Chen; Sarah Mahonski; Liping Xiao; Marja Hurley; Sumit Yadav; Tannin A. Schmidt

CARTILAGE. October 2020. doi:10.1177/1947603520962565

5 citations · 1 in 2025–2026

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2020 · Journal Articles

Correlation of Biomechanical Alterations under Gonarthritis between Overlying Menisci and Articular Cartilage2

Johannes Pordzik; Anke Bernstein; Julius Watrinet; Hermann O. Mayr; Sergio H. Latorre; Hagen Schmal; Michael Seidenstuecker

Appl. Sci. 2020, 10, 8673. https://doi.org/10.3390/app10238673

11 citations · 3 in 2025–2026

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2020 · Journal Articles

Evaluation of cartilage biomechanics and knee joint microenvironment after different cell-based treatments in a sheep model of early osteoarthritis

Francesca Veronesi; Matteo Berni; Gregorio Marchiori; Giorgio Cassiolas; Aurelio Muttini; Barbara Barboni; Lucia Martini; Milena Fini; Nicola Francesco Lopomo; Maurilio Marcacci; Elizaveta Kon

International Orthopaedics (SICOT) (2020). https://doi.org/10.1007/s00264-020-04701-y

26 citations · 6 in 2025–2026

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2020 · Journal Articles

Guided bone marrow stimulation for articular cartilage repair through a freeze-dried chitosan microparticle approach

Caroline D. Hoemann; Jessica Guzmán-Morales; Geneviève Picard; Gaoping Chen; Daniel Veilleux; Anik Chevrier; Sotcheadt Sim; Martin Garon; Eric Quenneville; Charles-Hubert Lafantaisie-Favreau; Michael D. Buschmann; Mark B. Hurtig

Materialia, 2020, 100609, ISSN 2589-1529, https://doi.org/10.1016/j.mtla.2020.100609.

6 citations · 0 in 2025–2026

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2020 · Journal Articles

Photochemically Activated Notch Signaling Hydrogel Preferentially Differentiates Human Derived Hepatoblasts to Cholangiocytes

Muhammad Rizwan; Ana Fokina; Tove Kivijärvi; Mina Ogawa; Markus Kufleitner; Onofrio Laselva; Laura J. Smith; Christine E. Bear; Shinichiro Ogawa; Gordon Keller; Molly S. Shoichet

Advanced Functional Materials. First published: 23 October 2020 https://doi.org/10.1002/adfm.202006116

26 citations · 7 in 2025–2026

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2020 · Journal Articles

Poromechanical Modeling of Porcine Knee Joint Using Indentation Map of Articular Cartilage

Mojtaba Zare; Daniel Tang; LePing Li

In: Ateshian G. Computer Methods, Imaging and Visualization in Biomechanics and Biomedical Engineering. CMBBE 2019. Lecture Notes in Computational Vision and Biomechanics, vol 36. Springer, Cham https://doi.org/10.1007/978-3-030-43195-2_7

2 citations · 0 in 2025–2026

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November 25, 2019 · Journal Articles

Dissolving used rubber tires

Sijia Zheng; Mengchen Liao; Yang Chen; Michael A. Brook

Green Chemistry 22 (2020), 94–102. First published online 25 November 2019. Original publisher PDF, retrieved from the open-access copy indexed by Semantic Scholar. Methods specify hemispherical indentation for Young’s modulus. Indentation trajectory/axis mode not specified; the current Indentation (Stiffness) category describes the stiffness measurement, not proof of uniaxial motion. No 3D normal mapping, hardness or active temperature-control claim.

45 citations · 17 in 2025–2026

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2019 · Journal Articles

Assessment of healthy trapeziometacarpal cartilage properties using indentation testing and contrast-enhanced computed tomography

Benjamin Dourthe; Reza Nickmanesh; David R. Wilson; Priscilla D'Agostino; Amit N. Patwa; Mark W. Grinstaff; Brian D. Snyder; Evie Vereecke

Clinical Biomechanics 61 (2019) 181–189 https://doi.org/10.1016/j.clinbiomech.2018.12.015

34 citations · 8 in 2025–2026

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2019 · Journal Articles

Multi-modal characterization of polymeric gels to determine the influence of testing method on observed elastic modulus

David M. Kingsley; Caitlin H. McCleery; Christopher D.L. Johnson; Michael T.K. Bramson; Deniz Rende; Ryan J. Gilbert; David T. Corr

Journal of the Mechanical Behavior of Biomedical Materials, available online 10 January 2019, https://doi.org/10.1016/j.jmbbm.2019.01.003

33 citations · 15 in 2025–2026

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2019 · Journal Articles

Setting up a pre-clinical human model for mechanical induced osteoarthritis to investigate potential pharmacological agents

E. Houtman; M. van Hoolwerff; R. Coutinho De Almeida; A. Rodriguez Ruiz; N. Lakenberg; H.E. Suchiman; M. Tuerlings; R.G. Timmermans; R.G. Nelissen; Y.F. Ramos; I. Meulenbelt

Osteoarthritis and Cartilage, April 2019, Volume 27, Supplement 1, Pages S80–S81. https://doi.org/10.1016/j.joca.2019.02.114

3 citations · 0 in 2025–2026

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2019 · Journal Articles

Viscoelasticity and histology of the human cartilage in healthy and degenerated conditions of the knee

Michael Seidenstuecker; Julius Watrinet; Anke Bernstein; Norbert P. Suedkamp; Sergio H. Latorre; Anastasija Maks; Hermann O. Mayr

Journal of Orthopaedic Surgery and Research, November 2019, 14:256. DOI: 10.1186/s13018-019-1308-5

37 citations · 10 in 2025–2026

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2018 · Journal Articles

Comparison of Regenerative Tissue Quality following Matrix-Associated Cell Implantation Using Amplified Chondrocytes Compared to Synovium-Derived Stem Cells in a Rabbit Model for Cartilage Lesions

Hagen Schmal; Justyna M. Kowal; Moustapha Kassem; Michael Seidenstuecker; Anke Bernstein; Katharina Böttiger; Tanshiyue Xiong; Norbert P. Südkamp; Eva J. Kubosch

Stem Cells International Volume 2018, Article ID 4142031, 12 pages https://doi.org/10.1155/2018/4142031

15 citations · 1 in 2025–2026

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2018 · Journal Articles

Glycation marker glucosepane increases with the progression of osteoarthritis and correlates with morphological and functional changes of cartilage in vivo

Catherine Legrand; Usman Ahmed; Attia Anwar; Kashif Rajpoot; Sabah Pasha; Cécile Lambert; Rose K. Davidson; Ian M. Clark; Paul J. Thornalley; Yves Henrotin; Naila Rabbani

Arthritis Research & Therapy 2018 20:131 https://doi.org/10.1186/s13075-018-1636-6

25 citations · 6 in 2025–2026

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2018 · Journal Articles

In Situ Cross-Linking of Poly (vinyl alcohol)/Graphene Oxide–Polyethylene Glycol Nanocomposite Hydrogels as Artificial Cartilage Replacement: Intercalation Structure, Unconfined Compressive Behavior, and Biotribological Behaviors

Yeqiao Meng; Lin Ye; Phil Coates; Peter Twigg

J. Phys. Chem. C, 2018, 122 (5), pp 3157–3167 DOI: 10.1021/acs.jpcc.7b12465

75 citations · 9 in 2025–2026

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2018 · Journal Articles

Investigating the role of in vivo cell cycle activation within mesenchymal stem cells in the regenerative potential of articular cartilage after injury

A.O. Masson; T.M. Underhill; W.B. Edwards; R.J. Krawetz

Osteoarthritis and Cartilage 26 (2018) S38 https://doi.org/10.1016/j.joca.2018.02.092

0 citations · 0 in 2025–2026

View publicationDOI ↗
2018 · Journal Articles

Quantifying the Effects of Different Treadmill Training Speeds and Durations on the Health of Rat Knee Joints

Jaqueline Lourdes Rios; Kevin Rudi Boldt; James William Mather; Ruth Anne Seerattan; David Arthur Hart; Walter Herzog

Sports Medicine - Open 2018 4:15 https://doi.org/10.1186/s40798-018-0127-2

27 citations · 4 in 2025–2026

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2017 · Meeting abstracts & presentations

Changes in Free Calcium Alter the Mechanical Properties of the Intervertebral Disc

I. Hadjab; M.P. Grant; L.M. Epure; M. Garon; E. Quenneville; J. Anthoniou; F. Mwale; M.D. Buschmann

International Conference on the Mechanics of Biomaterials and Tissues, Hawaii, USA, 1 2 Dec 2017, Podium O.48. Presented by E. Quenneville

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2017 · Journal Articles

Electromechanical probe and automated indentation maps are sensitive techniques in assessing early degenerated human articular cartilage

Sotcheadt Sim; Anik Chevrier; Martin Garon; Eric Quenneville; Patrick Lavigne; Alex Yaroshinsky; Caroline D. Hoemann; Michael D. Buschmann

Journal of Orthopaedic Research 35(4):858–867 (2017). First published online 22 June 2016.

50 citations · 8 in 2025–2026

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2017 · Journal Articles

Quantitative mechanical assessment of the whole prostate gland ex vivo using dynamic instrumented palpation

Steven J Hammer; Daniel W Good; Paul Scanlan; Javier Palacio-Torralba; Simon Phipps; Grant D Stewart; Will Shu; Yuhang Chen; S Alan McNeill; Robert L Reuben

Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine. 2017.

8 citations · 0 in 2025–2026

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December 19, 2016 · Journal Articles

Formation of Hyaline Cartilage Tissue by Passaged Human Osteoarthritic Chondrocytes

Vanessa J. Bianchi; Joanna F. Weber; Stephen D. Waldman; David Backstein; Rita A. Kandel

Tissue Engineering Part A. 2017;23(3-4):156–165. DOI:10.1089/ten.tea.2016.0262. Epub2016Dec19. Original article explicitly reprinted in Bianchi2019doctoral thesis Chapter2; methods verified in declared article reprint.

33 citations · 4 in 2025–2026

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2016 · Journal Articles

Addition of Mesenchymal Stem Cells to Autologous Platelet-Enhanced Fibrin Scaffolds in Chondral Defects: Does It Enhance Repair?

Laurie R. Goodrich; Albert C. Chen; Natasha M. Werpy; Ashley A. Williams; John D. Kisiday; Alvin W. Su; Esther Cory; Paul S. Morley; C. Wayne McIlwraith; Robert L. Sah; Constance R. Chu

The Journal of Bone and Joint Surgery. American volume 98(1), 23–34, 6 January 2016. Original abstract: English.

63 citations · 2 in 2025–2026

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2016 · Journal Articles

Guidelines for an optimized indentation protocol for measurement of cartilage stiffness - The effects of spatial variation and indentation parameters

Parisa R. Moshtagh; Behdad Pouran; Nicoline M. Korthagen; Amir A. Zadpoor; Harrie Weinans

Journal of Biomechanics 49(14) · September 2016 DOI: 10.1016/j.jbiomech.2016.09.020

39 citations · 4 in 2025–2026

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2014 · Meeting abstracts & presentations

Correlation of Non-destructive Electromechanical Probe (Arthro-BST) Assessment with Histological Scores, Biochemical Composition and Mechanical Properties in Human Knee Joints

Sim S; Chevrier A; Quenneville E; Garon M; Buschmann MD

Transactions of the 60th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA, USA, Poster 0439, 2014

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2014 · Journal Articles

Growth Factor Stimulation Improves the Structure and Properties of Scaffold-Free Engineered Auricular Cartilage Constructs

Renata G. Rosa; Paulo P. Joazeiro; Juares Bianco; Manuela Kunz; Joanna F. Weber; Stephen D. Waldman

PLoS ONE 9(8): e105170. doi:10.1371/journal.pone.0105170. (2014)

37 citations · 2 in 2025–2026

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2014 · Journal Articles

Low Magnitude High Frequency Vibration Accelerated Cartilage Degeneration but Improved Epiphyseal Bone Formation in Anterior Cruciate Ligament Transect Induced Osteoarthritis Rat Model

J. Qin; S.K.-H. Chow; A. Guo; W.-N. Wong; K.-S. Leung; W.-H. Cheung

Osteoarthritis and Cartilage. July 2014, Vol.22(7):1061–1067. (2014)

21 citations · 2 in 2025–2026

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2014 · Meeting abstracts & presentations

Mapping Biomechanical Properties of Mouse Articular Surfaces Using Indentation: Preliminary Results

J.-F. Lavoie; S. Sim; A. Moreau; C.-E. Aubin; E. Quenneville; M. Garon; M. D. Buschmann

BMES 2014, San Antonio. Submitted original English abstract and updated final poster retained separately. User confirmed both belong to the same presentation. Submitted abstract: 8-week C57BL/6 male mouse, 40 µm indentation; final poster: 15-week male Balb/c and STR/ort mice, 30 µm normal indentation. Original abstract is not silently updated with poster results. No public document URL established; PDFs available internally in Admin.

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2014 · Meeting abstracts & presentations

Novel Technique to Map the Biomechanical Properties of Entire Articular Surfaces Using Indentation to Identify Osteoarthritis-like Regions

Sim S; Chevrier A; Garon M; Quenneville E; Buschmann MD

Transactions of the 60th Annual Meeting of the Orthopaedic Research Society, 2014, New Orleans, LA, USA, 2015, Poster #2015

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2014 · Meeting abstracts & presentations

Novel Technique to Map the Biomechanical Properties of Entire Mice Articular Surfaces Using Indentation

S. Sim; J-F. Lavoie; A. Moreau; M. Garon; E. Quenneville; M. Buschmann

Osteoarthritis and Cartilage, 22(1), 541. World Congress on Osteoarthritis, April 2014, Paris, France.

2 citations · 0 in 2025–2026

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2013 · Journal Articles

Supplementation with platelet-rich plasma improves the in vitro formation of tissue-engineered cartilage with enhanced mechanical properties

Massimo Petrera; J.N. Amritha De Croos; Jonathan Iu; Mark Hurtig; Rita A. Kandel; John S. Theodoropoulos

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association. 2013;29(10):1685-1692.

36 citations · 4 in 2025–2026

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2012 · Journal Articles

Association of 3-dimensional cartilage and bone structure with articular cartilage properties in and adjacent to autologous osteochondral grafts after 6 and 12 months in a goat model

Elaine F. Chan; I-Ling Liu; Eric J. Semler; Harold M. Aberman; Timothy M. Simon; Albert C. Chen; Kate G. Truncale; Robert L. Sah

Cartilage, 3(3), 255-266. (2012)

17 citations · 2 in 2025–2026

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2012 · Journal Articles

Treatment of articular cartilage defects in the goat with frozen versus fresh osteochondral allografts: effects on cartilage stiffness, zonal composition, and structure at six months

Andrea L. Pallante; Simon Görtz; Albert C. Chen; Robert M. Healey; Derek C. Chase; Scott T. Ball; David Amiel; Robert L. Sah; William D. Bugbee

The Journal of bone and joint surgery. American volume. 2012;94(21):1984-1995.

69 citations · 6 in 2025–2026

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April 2010 · Journal Articles

The effect of intermittent static biaxial tensile strains on tissue engineered cartilage

Jackie C. Y. Fan; Stephen D. Waldman

Annals of Biomedical Engineering 38(4), 1672–1682 (2010). Complete original abstract retrieved from PubMed PMID 20087771 through Europe PMC. Exact article methods read in author-deposited text indexed on ResearchGate (Stephen D. Waldman); no local article PDF obtained. The thickness and indentation/relaxation characterization are separate from dead-weight biaxial stimulation. This is not the Fan thesis or the later JoVE protocol. Donor species remains unassigned pending the original sample-preparation section. Month precision comes from publisher citation metadata; no fabricated day.

39 citations · 1 in 2025–2026

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FAQ

How does the "Elastic Model in Indentation" works?

This tool allows for the computing and visualizing of the shear modulus (MPa) and the Young’s modulus (MPa) from an indentation test performed using a spherical indenter (Figure 1). This model is well adapted for the mechanical characterization of samples (with critical diameter (width) at least 5 times the indenter diameter) bonded on a flat rigid support (at least 10 times stiffer than the sample), for example: any sheet of material lying on a rigid chamber base (limited sliding at the interface can be assumed) or a cartilage layer attached to a thick sub-chondral bone. A user license is required to obtain the results of the elastic model in indentation (Software Add-On, contact Biomomentum to obtain your license).

Results analysis is performed considering the indentation mechanics of an infinitely wide elastic layer bonded to a rigid half-space which has been developed as a model for the layered geometry of cartilage and subchondral bone (Hayes et al., 1972). (Figure 2) shows a schematic representing the modeled situation.

Many parameters need to be specified in order to calculate the different material properties.

1. Indenter Shape is:

  • Spherical
  • Plane-Ended Cylindrical

2. Indenter radius in mm.

3. Poisson ratio can be selected from a drop-down list (Figure 3)


4. Position @ contact is – defines the position of the left cursor:

  • to be curvefit – will automatically find the position contact which will give the smallest mean squared error (mse)
  • the value at t0 – will automatically take the position contact at the start of the curve
  • the following value (mm) – the user need to specify the value in the corresponding field next to the drop-down list
  • cursor position – the user can drag the left cursor to the wanted position contact

5. Sample thickness is the:

  • position @ contact – will automatically find the position at contact (position of the left cursor)
  • following value (mm) – the user need to specify the value in the corresponding field next to the drop-down list

6. Curvefit is up to – defines the position of the right cursor:

  • peak load – will automatically take the position of the peak load
  • delta load (unit) – the user need to specify the value of the desired delta load in the corresponding field next to the drop-down list
  • delta position (mm) – the user need to specify the value of the desired delta position in the corresponding field next to the drop-down list

The error on the estimation of the best curve representing the stress relaxation curve is calculated using the root of the mean squares (RMS) method and is displayed under “RMSE”. For example, (Figure 4) shows parameters used for the “Normal Indentation” (Mach-1 Motion) function in an indentation testing protocol on ovine articular surfaces. Corresponding results are shown in (Figure 1).

Spherical Indentation Guide – Mach-1 Mechanical Tester – Biomomentum

Mach-1 Analysis – Elastic Model in Indentation – Parameters

Mach-1 Analysis – Elastic Model in Indentation – Poisson ratio choices

Mach-1 Analysis – Elastic Model in Indentation – Cartilage & Subchondral bone

Mach-1 Analysis – Elastic Model in Indentation – Example

How does the Normal Indentation function works?
This function precisely detects the height and orientation of the surface of the sample at the XY position and records the load (for multiaxial load cell only) while simultaneously moving the three linear stages at different speeds in order to move a spherical indenter with a predefined displacement profile along a virtual axis normal to the surface of the sample.

Parameters:
Z-CONTACT CRITERIA - The user specifies the load to be reached until the stage stops moving. The software analyzes the load-displacement curve and moves the stage back to the position where the load had started to increase (twice the load cell resolution) (refer to Find Contact function description).
SCANNING GRID - Specify the distance "d" from the test location of the 4 control points at the surface in the vicinity of the test location (xi,yi) = (-d,0), (d,0), (0,-d) and (0,d).
INDENTATION AMPLITUDE - This is the amplitude of the normal indentation. Full stage range is allowed. A positive amplitude will move the indenter toward the sample (compression).
INDENTATION VELOCITY - This is the velocity of the normal indentation. Refer to the specifications of your Mach-1™ model to learn of the velocity range allowed. In Mach-1 Motion, the speed is always specified in absolute value terms.
RELAXATION TIME - This is the time period during which the position is maintained at the commanded amplitude (relaxation period).

Spherical Indentation Guide – Mach-1 Mechanical Tester – Biomomentum

Mach-1 Motion – Normal Indentation Window

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