GBT-1118 Rescued Impaired Bone Formation but Failed to Rescue Material Properties in Humanized Sickle-Cell-Disease Murine Model

Editorial summary

A sickle-cell disease mouse model was used to examine whether GBT-1118 improves bone quality as well as blood parameters. Femoral composition and mechanical performance were assessed after treatment. Hematological improvements were not accompanied by recovery of the impaired bone material properties found in female animals.