Peau (cicatrisation)
Wound healing is the process by which a tissue repairs itself after trauma.
À propos de ce matériau
(En anglais seulement) Wound healing is the process by which a tissue repairs itself after trauma. In the context of wound healing of skin, the goal is to regenerate the tissue in a manner that the original functional and structural properties are restored, while minimizing the appearance of the scar. Wound healing studies are particularly useful in the preclinical phase to verify that a particular drug has no negative effect on natural healing capabilities. A straightforward way to evaluate the quality of the wounding process is to evaluate the tension load at rupture of the wound. Products designed to improve the outcome of wound healing need to demonstrate how they perform in restoring the mechanical function of the skin.
Configurations de test (13)
Tension
Compression Non-Confinée
Indentation (Raideur)
Cartographie 3D d'épaisseur
Cisaillement

Contrôle de la temperature
Stimulation Mécanique (Tension)
Capteurs analogues externes
Flux de caméra
Positionnement (manuel)
Positionnement (X Auto)
Positionnement (XY Auto)
Études de cas (2)
Ressources associées (2)
Littérature associée
Force-responsive biomaterials drive tissue repair by harnessing endogenous growth factors
Magdalene Y. Ho; Nuria Oliva; Christopher Basu; Marcos R. Rodriguez; Jose Antonio Duran-Mota; Divya M. Gollapalli; Victor G. Szwarcberg; Mo Akhavani; Kyle P. Quinn; Benjamin D. Almquist
Nat. Mater. (2026). Published: 27 July 2026
0 citations · 0 en 2025–2026
Chitosan-fibrinogen-thrombin matrix accelerates re-epithelialization and cornification in a rat wound healing model
Hind Lerhcha; Anik Chevrier; Marc Lavertu
NPJ Regenerative Medicine. 2026;11:43.
0 citations · 0 en 2025–2026
Skin-like micropumps transform human motion into fluidic flow via morphing valves
Rana Altay; Kari Olson; Johanna Brown; Andrea Pader; I. Emre Araci
Microsystems & Nanoengineering volume 12, Article number: 167 (2026), Published: 11 May 2026
1 citation · 1 en 2025–2026
Hydrazone-crosslinked poly(oligoethylene glycol methacrylate)-based hydrogels with physically entrapped phage effectively control Pseudomonas aeruginosa infections in a burn wound model
Sadru-Dean Walji; Isabella Jun; Evelyn Cudmore; Jagjeet Hara; Zeinab Hosseinidoust; Todd Hoare
Biomaterials Advances, Volume 177, 2025, 214403, ISSN 2772-9508, Published: December 2025
4 citations · 4 en 2025–2026
Development of a Chitosan and Autologous Cell-Based Implant for Cutaneous Wound Healing [English translation]
MASc thesis, Polytechnique Montréal, 2025 (degree/title-page year). Original French title: Développement d'un implant à base de chitosane et cellules autologues pour la guérison cutanée.
3D-bioprinted tri-layered cellulose/collagen-based drug-eluting fillers for the treatment of deep tunneling wounds
Mano Govindharaj; Noura Al Hashimi; Soja S. Soman; Jiarui Zhou; Safeeya AlAwadhi; Sanjairaj Vijayavenkataraman
Bio-des. Manuf. (2024), Published: 22 October 2024
4 citations · 4 en 2025–2026
A Nanocomposite Dynamic Covalent Cross-Linked Hydrogel Loaded with Fusidic Acid for Treating Antibiotic-Resistant Infected Wounds
Samaneh Toufanian; Jody Mohammed; Erica Winterhelt; Andrew Lofts; Ridhdhi Dave; Brian K. Coombes; Todd Hoare
ACS Appl. Bio Mater, Publication Date: February 23, 2024
12 citations · 8 en 2025–2026
How to Keep Myofibroblasts under Control: Culture of Mouse Skin Fibroblasts on Soft Substrates
Dong Ok Son; Raquel Benitez; Li Diao; Boris Hinz
Journal of Investigative Dermatology, ISSN 0022-202X, Published: 29 July 2024
18 citations · 17 en 2025–2026
Signaling modality within gp130 receptor enhances tissue regeneration
Ruzanna Shkhyan; Candace Flynn; Emma Lamoure; Ben Van Handel; Arijita Sarkar; Jinxiu Li; Jesse York; Nicholas Banks; Robert Van der Horst; Nancy Q. Liu; Siyoung Lee; Paul Bajaj; Kanagasabai Vadivel; Hans I-Chen Harn; Thomas Lozito; Jay R. Lieberman; Cheng-Ming Chuong; Mark S. Hurtig; Denis Evseenko
bioRxiv, Posted January 05, 2022
1 citation · 0 en 2025–2026
Wound Healing Revealed by a Novel Automated Indentation Technique
Sim S; Garon M; Quenneville E; Buschmann MD
Canadian Connective Tissue Conference 2015 in Quebec, Canada
0 citations · 0 en 2025–2026
Validation of a surgical wound healing model in Sprague-Dawley rats
Authier S; Fournier S; Chaurand F; Gordon C; Garon M; Cloutier L; Troncy E
Paper presented at the 27th Annual Meeting of the American College of Toxicology (November 2006)
FAQ
Qu'est-ce que l'allongement à la rupture?+
Comment fonctionne le modèle élastique en indentation "Elastic Model in Indentation"?+
(En anglais seulement) This tool allows for the computing and visualizing of the shear modulus (MPa) and the Young’s modulus (MPa) from an indentation test performed using a spherical indenter (Figure 1). This model is well adapted for the mechanical characterization of samples (with critical diameter (width) at least 5 times the indenter diameter) bonded on a flat rigid support (at least 10 times stiffer than the sample), for example: any sheet of material lying on a rigid chamber base (limited sliding at the interface can be assumed) or a cartilage layer attached to a thick sub-chondral bone. A user license is required to obtain the results of the elastic model in indentation (Software Add-On, contact Biomomentum to obtain your license).
Results analysis is performed considering the indentation mechanics of an infinitely wide elastic layer bonded to a rigid half-space which has been developed as a model for the layered geometry of cartilage and subchondral bone (Hayes et al., 1972). (Figure 2) shows a schematic representing the modeled situation.
Many parameters need to be specified in order to calculate the different material properties.
1. Indenter Shape is:
- Spherical
- Plane-Ended Cylindrical
2. Indenter radius in mm.
3. Poisson ratio can be selected from a drop-down list (Figure 3)
4. Position @ contact is – defines the position of the left cursor:
- to be curvefit – will automatically find the position contact which will give the smallest mean squared error (mse)
- the value at t0 – will automatically take the position contact at the start of the curve
- the following value (mm) – the user need to specify the value in the corresponding field next to the drop-down list
- cursor position – the user can drag the left cursor to the wanted position contact
5. Sample thickness is the:
- position @ contact – will automatically find the position at contact (position of the left cursor)
- following value (mm) – the user need to specify the value in the corresponding field next to the drop-down list
6. Curvefit is up to – defines the position of the right cursor:
- peak load – will automatically take the position of the peak load
- delta load (unit) – the user need to specify the value of the desired delta load in the corresponding field next to the drop-down list
- delta position (mm) – the user need to specify the value of the desired delta position in the corresponding field next to the drop-down list
The error on the estimation of the best curve representing the stress relaxation curve is calculated using the root of the mean squares (RMS) method and is displayed under “mse”. For example, (Figure 4) shows parameters used for the “Normal Indentation” (Mach-1 Motion) function in an indentation testing protocol on ovine articular surfaces. Corresponding results are shown in (Figure 1).
Spherical Indentation Guide – Mach-1 Mechanical Tester – Biomomentum
Mach-1 Analysis – Modèle élastique en Indentation – Paramètres
Mach-1 Analysis – Modèle élastique en indentation – Poisson ratio choix
Mach-1 Analysis-Modèle élastique dans l’indentation–Cartilage & os sous-chondral
Qu'est-ce que la viscoélasticité?+
LAB MODULE – Torsion of Disk-Shaped Samples – Student Version


