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SIRT2 transgenic over‐expression does not impact lifespan in mice

  • par garon@biomomentum.com

Lindsay E. Wu; Corrine E. Fiveash; Nicholas L. Bentley; Myung‐Jin Kang; Hemna Govindaraju; Jayne A. Barbour; Brendan P. Wilkins; Sarah E. Hancock; Romanthi Madawala; Abhijit Das; Hassina Massudi; Catherine Li; Lynn‐Jee Kim; Ashley S. A. Wong; Maria B. Marinova; Ghazal Sultani; Abhirup Das; Neil A. Youngson; David G. Le Couteur; David A. Sinclair; Nigel Turner
Aging Cell. 2023;22(12):e14027.

https://doi.org/10.1111/acel.14027

3 citations · 2 en 2025–2026

Les titres, résumés et légendes des publications sont présentés en anglais.

Editorial summary

Transgenic mice overexpressing SIRT2 were evaluated for lifespan and age-related functional outcomes. The investigation included physiological and tissue-level measurements under different diet conditions. Increased SIRT2 expression produced selected biochemical differences but did not lead to a broad improvement in health or longevity.

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Mach-1 Analysis sert à analyser les mesures de charge et de déplacement des essais de flexion à trois points d’os longs de souris.

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