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Regenerative engineering of long bones using the small molecule forskolin

  • par garon@biomomentum.com

Guleid M. Awale; Mohammed A. Barajaa; Ho-Man Kan; Amir Seyedsalehi; Ga Hie Nam; Fatemeh S. Hosseini; Chinedu C. Ude; Tannin A. Schmidt; Kevin W.-H. Lo; Cato T. Laurencin
Proceedings of the National Academy of Sciences of the United States of America. 2023;120(22):e2219756120.

https://doi.org/10.1073/pnas.2219756120

20 citations · 16 en 2025–2026

Les titres, résumés et légendes des publications sont présentés en anglais.

Editorial summary

A fibrin–PLGA scaffold was developed for localized delivery of forskolin to promote bone regeneration. Cell studies examined osteogenic differentiation, followed by evaluation in rabbit radial defects. The work compares repair outcomes and explores a small-molecule alternative to protein-based osteogenic factors.

Utilisation des équipements

Flexion à trois points jusqu’à rupture d’avant-bras de lapin prélevés avec le Mach-1 Mechanical Tester.

Matériaux (1)

Configurations de test (1)

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