P2Y2 Inhibition Modifies the Anabolic Response to Exercise in Adult Mice

Editorial summary

This mouse study examines how inhibition of the P2Y2 receptor changes skeletal responses to exercise. Adult animals received the receptor inhibitor and were evaluated for bone formation, remodeling and mechanical properties under exercised and comparison conditions. The intervention modified the anabolic response at the periosteal surface and affected endocortical formation and osteoclast-related outcomes. Mechanical testing of tibiae provided a structural assessment alongside tissue analyses. The findings suggest that P2Y2 signaling participates in the regulation of bone adaptation, while distinguishing effects associated with exercise from those observed independently of it.