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Inhibiting thyroid activation in aged human explants prevents mechanical induced detrimental signalling by mitigating metabolic processes

  • par garon@biomomentum.com

Evelyn Houtman; Margo Tuerlings; H Eka D Suchiman; Nico Lakenberg; Frederique M F Cornelis; Hailiang Mei; Demiën Broekhuis; Rob G H H Nelissen; Rodrigo Coutinho de Almeida; Yolande F M Ramos; Rik J Lories; Luis J Cruz; Ingrid Meulenbelt
Rheumatology (Oxford, England). 2022;62(1):457-466.

https://doi.org/10.1093/rheumatology/keac202

7 citations · 2 en 2025–2026

Les titres, résumés et légendes des publications sont présentés en anglais.

Editorial summary

Aged human osteochondral explants were subjected to injurious mechanical loading to investigate the protective effects of iopanoic acid. Repeated dosing and nanoparticle delivery were examined using tissue and gene-expression outcomes. The intervention reduced several damaging responses associated with the experimental mechanical insult.

Utilisation des équipements

Le Mach-1 Mechanical Tester impose une compression dynamique délétère répétée à des explants ostéochondraux humains.

Matériaux (1)

Configurations de test (1)

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