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Rupture mechanics of blood clots: Influence of fibrin network structure on the rupture resistance

  • par garon@biomomentum.com

Ranjini K. Ramanujam; Farkhad Maksudov; Rebecca A. Risman; Rustem I. Litvinov; John W. Weisel; John L. Bassani; Valeri Barsegov; Prashant K. Purohit; Valerie Tutwiler
Acta biomaterialia. 2024;190:329-343.

https://doi.org/10.1016/j.actbio.2024.10.004

15 citations · 15 en 2025–2026

Les titres, résumés et légendes des publications sont présentés en anglais.

Editorial summary

Human plasma clots were prepared with different tissue-factor concentrations to study relationships between fibrin structure and fracture resistance. Imaging, mechanical experiments and modeling showed that toughness varied nonmonotonically with coagulation conditions. The work distinguishes resistance to crack propagation from conventional viscoelastic measures.

Utilisation des équipements

Le Mach-1 Mechanical Tester sert aux essais de traction et de rupture d’éprouvettes entaillées de caillots de plasma humain.

Matériaux (1)

Configurations de test (2)

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