Properties of Biopolymer Films in Ionic Solutions and Their Applications as 3D Printed Personalized Wound Dressings

D.P. Ramos
University of Toronto (Canada), ProQuest Dissertations Publishing, 2019. 13805509.

Les titres, résumés et légendes des publications sont présentés en anglais.

This thesis describes the effects of ionic solutions on biopolymer films and the development of a 3D printed personalized wound dressing.

Chitosan, gelatin, and composite chitosan/gelatin films were exposed to NaCl, Na2SO4, and CaCl2 solutions with varying ionic strength and their swelling and dissolution properties were measured. In addition, the release of the small ionic molecules Rhodamine B and Eosin Y from films into NaCl solutions of varying ionic strength was monitored.

Next, a shear-thinning mixture of cellulose nanocrystals and chitosan-methacrylate was extruded with various patterns and polymerized by ultraviolet light irradiation or elevated temperature to form hydrogel wound dressings. Antimicrobial silver nanoparticles, a model protein (bovine serumalbumin), and an antibiotic (gentamicin) were added to the hydrogel mixtures and their release from the dressings was monitored. In addition, phenol red-methacrylate was co-polymerized into the hydrogel dressing and exhibited a pH-responsive colour change suitable for the detection of infection.

Utilisation des équipements

Cette thèse examine le comportement de films de biopolymères dans des solutions ioniques et la fabrication de pansements hydrogel personnalisés. Le résumé disponible décrit des mesures de gonflement, de dissolution et de libération, ainsi que l’extrusion et la polymérisation des mélanges destinés aux pansements. Il ne précise ni le rôle d’un Mach-1 ni un protocole d’essai mécanique pour les films ou les pansements.