Injectable Dual‐Crosslinked Poly(oligo(Ethylene Glycol) Methacrylate) Hydrogels Inspired by Mussel Adhesion for Cutaneous Wound Healing and Functional Tissue Regeneration

Editorial summary

The investigators designed injectable hydrogels based on poly(oligo(ethylene glycol) methacrylate) using complementary crosslinking mechanisms inspired by mussel adhesion. Formulation studies assessed gel formation, mechanical properties and tissue adhesion, followed by biological evaluation in a mouse wound model. The dual-network approach enabled rapid gelation and adjustable material performance. The animal experiments examined wound closure, inflammation and tissue regeneration after application of the material. Together, the findings support further preclinical development of an adhesive hydrogel platform; clinical safety and effectiveness for human wound treatment remain to be established.