IN VITRO OSTEOCHONDRAL MODEL GUIDED BY CARTILAGE ELECTROMECHANICAL PROPERTIES

Abstract — Editorial summary

This conference study used Benchtop Arthro-BST mapping to guide collection of equine osteochondral plugs for an in vitro osteoarthritis model. Seventeen plugs from four femoral blocks were cultured for six days as controls, after compressive injury, or after injury with TNFα. Initial electromechanical values varied both between blocks and within a block and were associated with subsequent mechanical changes and glycosaminoglycan release. Plugs in different initial QP ranges responded differently to injury and inflammation. The study suggests that initial mapping can help account for biological variability when developing tunable cartilage degeneration models.

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