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Gamma Irradiation of Poly(lactide‐co‐glycolide) Scaffolds Reduces the Mechanical Stability and Function of Islet Grafts in Diabetic Nonhuman Primates

  • par garon@biomomentum.com

Jessica L. King; Christopher Spencer; Richard Youngblood; Kelly Crumley; Elizabeth Bealer; Peter D. Rios; Ira Joshi; Sofia Ghani; Douglas Isa; James J. McGarrigle; David Cook; Conor Locke; Adam Abraham; Andrea Clark; José Oberholzer; Lonnie D. Shea
Biotechnology and Bioengineering. 2026;123(3):742-751.

https://doi.org/10.1002/bit.70134

0 citations · 0 en 2025–2026

Les titres, résumés et légendes des publications sont présentés en anglais.

Editorial summary

Microporous polymer scaffolds for extrahepatic islet transplantation were investigated in mouse and nonhuman primate models. Sterilization-related fragility motivated changes in scaffold formulation. The work examines how polymer content, porosity and mechanical stability interact with islet compatibility and transplant outcomes.

Utilisation des équipements

Compression d’échafaudages PLG irradiés ou non avec le Mach-1 Mechanical Tester; le matériau mesuré est l’échafaudage.

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Configurations de test (1)

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