Anand O. Masson; Jay Devine; Nabangshu Das; Clarissa R. Coveney; Benedikt Hallgrimsson; Zun Liu; Terence D. Capellini; Jeff A. Biernaskie; W. Brent Edwards; Roman J. Krawetz
The FASEB Journal. 2025;39(16):e70974.
https://doi.org/10.1096/fj.202501775r
2 citations · 2 en 2025–2026
Les titres, résumés et légendes des publications sont présentés en anglais.
Editorial summary
The investigators compared femoral morphology in mice lacking proteoglycan 4 with that of wild-type animals during growth and adulthood. Imaging and tissue analyses were combined with cartilage indentation and thickness measurements to relate joint shape to mechanical characteristics. Prg4 deficiency was associated with changes in distal femoral dimensions and articular cartilage, supporting a role for this protein in joint development and maintenance. The study links altered lubrication-related biology with joint morphology and cartilage properties in a mouse model. These animal findings do not establish an equivalent disease mechanism or treatment effect in patients.
Utilisation des équipements
Note de référencement — Cartilage fémoral de souris : mesures par indentation et sondage d’épaisseur avec le Mach-1 v500csst.
Matériaux (1)
Cartilage articulaire
Configurations de test (3)
Cartographie 3D en indentation normale
Indentation (Raideur)
