Détection de la dégénérescence du cartilage articulaire par la distribution spatiale des potentiels d’écoulement

Abstract — Editorial summary

This thesis investigated whether spatial streaming-potential measurements reveal cartilage degradation. Bovine explants were cultured with degradation-inducing agents and assessed using biochemical assays, mechanical loading and a linear microelectrode array. Interleukin-1α treatment caused proteoglycan loss and collagen damage, alongside reduced stiffness and altered electrical potential profiles. Changes near the tissue edge appeared early in the culture period. Saline concentration and signal filtering also affected the measurements. The work supports spatially resolved electromechanical measurements as laboratory indicators of matrix deterioration, while identifying experimental factors that must be controlled.

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