Chitosan/Platelet‐Rich Plasma Implants in an Ovine Arthroscopic Model of Meniscus Repair

Abstract — Editorial summary

A fully arthroscopic sheep model tested whether chitosan combined with platelet-rich plasma improves repair of sutured radial meniscal tears. Twenty-two ewes received one of two implant doses, platelet-rich plasma alone, or sutures alone. Mechanical testing assessed menisci and cartilage, while Arthro-BST assessed articular cartilage electromechanics. At six months, all operated joints showed osteoarthritic changes, but implant-treated groups had better structural appearance and instantaneous mechanical properties. Early observations confirmed implant retention and cell recruitment. This preclinical study suggests a protective effect on joint tissues, without establishing efficacy in human meniscal repair.

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