Characterization and In Vitro Cytotoxicity Safety Screening of Fractionated Organosolv Lignin on Diverse Primary Human Cell Types Commonly Used in Tissue Engineering

Editorial summary

Fractionated organosolv lignin was evaluated for compatibility with several human cell types and for incorporation into hydrogels. The work investigates effects of molecular weight, concentration and preparation conditions. Lignin-containing gels were assessed for cellular responses and mechanical properties relevant to tissue-engineering substrates.