Biotribology of meniscus degeneration: correlations between frictional, structural and compressive properties

Introduction

Despite extensive knowledge of how degeneration-related structural changes affect the compressive properties of the meniscus, the associated tribological changes remain poorly understood. Moreover, both functionalities have largely been investigated independently, leaving a knowledge gap regarding possible interrelationships. The aim of this study was to elucidate how alterations in meniscus biomechanical and structural properties affect the tissues tribological properties.

Methods

Human menisci with varying degrees of degeneration were collected from patients undergoing total knee replacement surgery. The compressive meniscus properties were determined using established indentation and compression tests, while the tribological properties were analyzed under simulated gait conditions. Macroscopic as well as microscopic degeneration was assessed by means of Pauli scoring and quantitative histology of glycosaminoglycan, collagen and proteoglycan-4 content. Statistically, linear mixed model analysis and Spearman correlation were applied.

Results

Higher macroscopic degeneration severity was associated with both increased friction (ρ = 0.30–0.32, p < 0.05) and reduced compressive stiffness (ρ = 0.30, p < 0.05). Increased friction coefficients were significantly associated with lower initial elastic properties (ρ = 0.30–0.42, p < 0.05) and higher viscoelastic relaxation behavior (ρ = 0.30–0.35, p < 0.05).

Discussion

Degenerative changes in the meniscus manifest themselves in a coupled tribological-functional impairment. The interaction between altered friction and compressive properties could represent a mutually reinforcing, degeneration-promoting feedback loop. To prevent a potential function-driven vicious cycle, disease modifying therapies may target the meniscus’ dual functionality in gonarthrosis progression.