Lung
Lungs are a pair of organs in the respiratory system.
About this material
Lungs are a pair of organs in the respiratory system. The mechanical behavior of lungs is a reflection of the gross tissue mechanics rather than a reflection of its individual components. The mechanical properties of lungs are studied to learn about: their structural function in the body, the effects of pathologies in lung mechanics and related clinical issues, the development of engineered constructs of lungs and research in lung physiology.
Test configurations (9)
Unconfined Compression
Burst
Dynamic Mechanical Analysis
Confined Compression

Temperature Control
External Analog Sensors
Digital Image Correlation (DIC)
Camera Feed
Related resources (1)
Related literature
Targeted immunotherapy rescues pulmonary fibrosis by reducing activated fibroblasts and regulating alveolar cell profile
Jing Yan; Song-Yu Wang; Qi Su; Min-Wen Zou; Zi-Yue Zhou; Jian Shou; Yunlong Huo
Nat Commun 16, 3748 (2025), Published: 21 April 2025
63 citations · 63 in 2025–2026
Acute Effects and Mechanisms of Macrophage Contact Formation with Fibroblasts
University of Toronto. PhD thesis, November 2024. Original abstract: English. Hydrogel methods include explicitly attributed work reproduced from Chen et al. 2024; no independent experiment count is inferred.
0 citations · 0 in 2025–2026
Comparison of Aerodynamic and Elastic Properties in Tissue and Synthetic Models of Vocal Fold Vibrations
Jacob Michaud-Dorko; Charles Farbos de Luzan; Gregory R. Dion; Ephraim Gutmark; Liran Oren
Bioengineering 2024, 11(8), 834, Published: 15 August 2024
9 citations · 7 in 2025–2026
Extracellular Matrix-mediated Lung Epithelial Cell Differentiation
PhD thesis, University of Toronto, 2016 (degree/title-page year).
0 citations · 0 in 2025–2026
Experimental Evidence of Mechanical Isotropy in Porcine Lung Parenchyma
Benjamin Weed; Sourav Patnaik; Mary Rougeau-Browning; Bryn Brazile; Jun Liao; Raj Prabhu; Lakiesha Williams
Materials 2015, 8 , 2454-2466; doi:10.3390/ma8052454
17 citations · 4 in 2025–2026
Extracellular matrix structure and tissue stiffness control postnatal lung development through the lipoprotein receptor–related protein 5/Tie2 signaling system
Tadanori Mammoto; Elisabeth Jiang; Amanda Jiang; Akiko Mammoto
American Journal of Respiratory Cell and Molecular Biology 49(6) (2013), 1009–1018. Originally published in press 10 July 2013. Original abstract from PubMed/Europe PMC, PMID 23841513. Methods: publisher PDF indexed text, printed page 1010, Mechanical Measurement of Lungs. Live PDF download unavailable after publisher migration; no PDF claimed as archived.
71 citations · 6 in 2025–2026
Control of lung vascular permeability and endotoxin-induced pulmonary oedema by changes in extracellular matrix mechanics
Akiko Mammoto; Tadanori Mammoto; Mathumai Kanapathipillai; Chong Wing Yung; Elisabeth Jiang; Amanda Jiang; Kristopher Lofgren; Elaine P.S. Gee; Donald E. Ingber
Nat Commun. 2013;4:1759. doi: 10.1038/ncomms2774.
149 citations · 25 in 2025–2026
Southern Regional Center for Lightweight Innovative Design
Mississippi State University. Final Scientific & Technical Report, December 2012. Award DE-FC26-06NT42755. OSTI 1062654.
0 citations · 0 in 2025–2026
FAQ
How does the "Sinusoid" model works?+
This feature is used to obtain the Frequency, Amplitude and Offset of a sinusoidal signal. A blue line displays the theoretical sinusoid with the Frequency, Amplitude and Offset obtained (Figure 1). The values of the Frequency, Amplitude and Offset are indicated in the "Results" field. The units vary according to the graph’s axes.
This feature can also be used for sinusoidal stimulus-response analysis. Sinusoidal stimulus shall be selected on the x-axis and the sinusoidal response on the y-axis. The Modulus is the ratio of the response Amplitude over the stimulus Amplitude. The Phase is the phase difference between the response and the stimulus. The Modulus’ is computed as the Modulus*Cos(Phase) and the Modulus” is computed as the Modulus*Sin(Phase). A blue line displays the theoretical sinusoidal stimulus-response with the Frequency, Modulus and Phase obtained (Figure 2). The values of the Modulus and Phase are indicated in the “Results” field. The units vary according to the graph’s axes.
One use for this feature would be to compute material properties by multiplying the Modulus obtained by the appropriate geometric factors. For example, the Young’s Modulus can be obtained during uniaxial compression or tension on cylindrical sample with t/pi*r2 as the geometric factor, t is the thickness and r is the radius of the sample.
Mach-1 Analysis – Sinusoid – Example for stimulus-response analysis
What is the elasticity?+
LAB MODULE – Unconfined Compression of Hydrogel Disks – Student Version
