The Mach-1™ is a micromechanical testing system commercially available since 1999. This high resolution system is used in various testing configurations for evaluating the mechanical properties of tissues and materials. Due to its small size and high resolution, the Mach-1™ offers versatility in numerous biomaterial and biological applications. Each Mach-1™ system is equipped with a computer and easy-to-use software for specific applications.

"V" Class Mach-1™ - The Best Value

The "V" Class Mach-1™ is renowned for the value it offers in combining cost-effectiveness and high performance. The "V" Class was designed for multiple axis testing. Compression, tension, shear, torsion - the "V" Class can apply them all in various modes including dynamic, static and waveform loading.

This multiple axis testing system is offered in 4 models:

• Compression/tension (V500c)
• Compression/tension and shear (V500cs)
• Compression/tension and torsion (V500ct)
• Compression/tension, shear and torsion (V500cst)

Characteristics

• Designed for multiple axis loading
• Excellent for large displacements
• Fits into a standard tissue culture incubator

Technical Specifications

"V" Class MACH-1™	Compression/ Tension and Shear	Torsion
Travel Range	100 mm	360°
Encoder Resolution	0.5µm or 0.1µm	0.0005°
Uni-directional Repeatability	1.5µm or 0.4µm	0.002°
Maximum Velocity	100 mm/s	80°/s
Load Capacity	±50 N	±1 N·m

Scientific Publications by Mach-1 Users

2009

Yip CY, Chen JH, Zhao R, Simmons CA. (2009) Calcification by valve interstitial cells is regulated by the stiffness of the extracellular matrix. Arterioscler Thromb Vasc Biol. 29(6):936-42. PubMed

Dare EV, Griffith M, Poitras P, Kaupp JA, Waldman SD, Carlsson DJ, Dervin G, Mayoux C, Hincke MT. (2009) Genipin Cross-Linked Fibrin Hydrogels for in vitro Human Articular Cartilage Tissue-Engineered Regeneration. Cells Tissues Organs. PubMed

Sergerie K, Lacoursiere MO, Levesque M, Villemure I. (2009) Mechanical properties of the porcine growth plate and its three zones from unconfined compression tests. J Biomech. 42(4):510-6. PubMed

Sergerie K, Gennaro B, Eveno A-S, Dubois-Rioux M-C, Lacoursiere M-O, Villemure I. (2009) Intrinsic Mechanical Properties of Porcine Growth Plates Vary With Developmental Stages. Transactions of the 55th Annual Meeting of the Orthopaedic Research Society, Las Vegas, NV, USA, 34:328. Abstract

2008

De Croos JN, Pilliar RM, Kandel RA. (2008) AP-1 DNA binding activity regulates the cartilage tissue remodeling process following cyclic compression in vitro. Biorheology. 45(3-4):459-69. PubMed

Leipzig ND, Shoichet M. (2008) Neural stem cell 2D and 3D responses to substrate stiffness. Biomedical Engineering Society Annual Fall Meeting. St. Louis, MO, USA.

Leipzig ND, Shoichet M. (2008) Photopolymerizable chitosan for studying the effects of substrate stiffness on neural stem cell differentiation. World Biomaterials Congress 2008. Amsterdam, The Netherlands.

Vizesi F, Jones C, Lotz N, Gianoutsos M, Walsh WR. (2008) Stress relaxation and creep: viscoelastic properties of common suture materials used for flexor tendon repair. J Hand Surg [Am]. 33(2):241-6. PubMed

Sergerie K, Villemure I, Lacoursiere MO. (2008) Mechanical Properties of the Porcine Growth Plate and its Three Zones from Unconfined Compression Tests. Transactions of the 54th Annual Meeting of the Orthopaedic Research Society, San Francisco, CA, USA, 33:621. Abstract

Williams LN, Elder SH, Bouvard JL, Horstemeyer MF. (2008) The anisotropic compressive mechanical properties of the rabbit patellar tendon. Biorheology. 45(5):577-86. PubMed

2007

Wu JZ, Cutlip RG, Andrew ME, Dong RG. (2007) Simultaneous determination of the nonlinear-elastic properties of skin and subcutaneous tissue in unconfined compression tests. Skin Res Technol. 13(1):34-42. PubMed

Cho HS, Park KD, Shim JW, Elder S, Huang J, Min BH, Robertson JT, Hasty KA. (2007) Construction of a tissue-engineered annulus fibrosus. Transactions of the 53rd Annual Meeting of the Orthopaedic Research Society, San Diego, CA, USA, 32:1589. Abstract

De Croos JN, Jang B, Dhaliwal SS, Grynpas MD, Pilliar RM, Kandel RA. (2007) Membrane type-1 matrix metalloproteinase is induced following cyclic compression of in vitro grown bovine chondrocytes. Osteoarthritis Cartilage. 15(11):1301-10. PubMed

Waldman SD, Couto DC, Grynpas MD, Pilliar RM, Kandel RA. (2007) Multi-axial mechanical stimulation of tissue engineered cartilage: review. Eur Cell Mater. 13:66-73; discussion 73-4. PubMed

Birdwell JA, Solomon JH, Thajchayapong M, Taylor MA, Cheely M, Towal RB, Conradt J, and Hartmann MJZ (2007) Biomechanical models for radial distance determination by the rat vibrissal system. Journal of Neurophysiology 98: 2439-2455. Article

Leipzig ND, Shoichet M. (2007) Neural progenitor cell differentiation and the effects of substrate stiffness. Stem Cell Network Annual General Meeting. Toronto, ON, Canada.

2006

Mulhbacher J, Ispas-Szabo P, Ouellet M, Alex S, Mateescu MA. (2006) Mucoadhesive properties of cross-linked high amylose starch derivatives. Int J Biol Macromol. 40(1):9-14. PubMed

Horstman CL, McLaughlin RM, Elder SH, Pool RR, Read RW, Boyle CR. (2006) Biomechanical and metabolic changes within rabbit articular cartilage following treatment with radiofrequency energy. Podium presentation at the 2nd Annual World Veterinary Orthopaedic Congress, Keystone, CO, USA.

Waldman SD, Couto DC, Grynpas MD, Pilliar RM, Kandel RA. (2006) A single application of cyclic loading can accelerate matrix deposition and enhance the properties of tissue-engineered cartilage. Osteoarthritis Cartilage. 14(4):323-30. PubMed

Wu JZ, Cutlip RG, Welcome D, Dong RG. (2006) Estimation of the viscous properties of skin and subcutaneous tissue in uniaxial stress relaxation tests. Biomed Mater Eng. 2006;16(1):53-66. PubMed

Valverde-Franco, G., Binette, J. S., Li, W., Wang, H., Chai, S., Laflamme, F., Tran-Khanh, N., Quenneville, E., Meijers, T., Poole, A. R., Mort, J. S., Buschmann, M. D. and Henderson, J. E. (2006). Defects in Articular Cartilage Metabolism and Early Arthritis in Fibroblast Growth Factor Receptor 3 Deficient Mice. Hum Mol Genet 15(11): 1783-92. PubMed

De Croos JN, Dhaliwal SS, Grynpas MD, Pilliar RM, Kandel RA. (2006) Cyclic compressive mechanical stimulation induces sequential catabolic and anabolic gene changes in chondrocytes resulting in increased extracellular matrix accumulation. Matrix Biol. 25(6):323-31. PubMed

2005

Williams GM, Klein TJ, Sah RL. (2005) Cell density alters matrix accumulation in two distinct fractions and the mechanical integrity of alginate-chondrocyte constructs. Acta Biomater. 1(6):625-33. PubMed

Binette JS, Laflamme F, Li W, Valverde-Franco G, Tran-Khanh N, Quenneville E, Henderson J.E, and Buschmann MD. (2005) Novel Biomechanical Indentation Test Demonstrates Joint Surface Weakening in Mice Lacking Fibroblast Growth Factor Receptor 3 (FGFR3). 11th Canadian Connective Tissue Conference, Montreal, QC, Canada.

2004

Acton D, Perry A, Evans R, Butler A, Stephens P, Bruce W, Goldberg J, Sonnabend D, Walsh WR. (2004) The effect of two nonresorbable suture types on the mechanical performance over a metal suture anchor eyelet. Knee Surg Sports Traumatol Arthrosc. 12(2):165-8. PubMed

Valverde-Franco, G., Liu, H., Davidson, D., Chai, S., Valderrama-Carvajal, H., Goltzman, D., Ornitz, D. M. and Henderson, J. E. (2004). Defective Bone Mineralization and Osteopenia in Young Adult Fgfr3-/- Mice. Hum Mol Genet 13(3): 271-84. PubMed

Bae WC, Law AW, Amiel D, Sah RL. (2004) Sensitivity of indentation testing to step-off edges and interface integrity in cartilage repair. Ann Biomed Eng. 32(3):360-9. PubMed

Nugent, GE, Law, AW, Wong EG, Temple MM, Bae WC, Chen AC, Kawcak CE, Sah RL. (2004) Site- and exercise-related variation in structure and function of cartilage from equine distal metacarpal condyle. Osteoarthritis Cartilage.12(10):826-33. PubMed

Waldman SD, Spiteri CG, Grynpas MD, Pilliar RM, Kandel RA. (2004) Long-term intermittent compressive stimulation improves the composition and mechanical properties of tissue-engineered cartilage. Tissue Eng. 10(9-10):1323-31. PubMed

Wu JZ, Brumfield A, Miller GR, Metheny R, Cutlip RG. (2004) Comparison of mechanical properties of rat tibialis anterior tendon evaluated using two different approaches. Biomed Mater Eng. 14(1):13-22. PubMed

2003

Waldman SD, Spiteri CG, Grynpas MD, Pilliar RM, Kandel RA. (2003) Long-term intermittent shear deformation improves the quality of cartilaginous tissue formed in vitro. J Orthop Res. 21(4):590-6. PubMed

Waldman SD, Spiteri CG, Grynpas MD, Pilliar RM, Hong J, Kandel RA. (2003) Effect of biomechanical conditioning on cartilaginous tissue formation in vitro. J Bone Joint Surg Am. 85-A Suppl 2:101-5. PubMed

Wu JZ, Dong RG, Smutz WP, Schopper AW. (2003) Nonlinear and viscoelastic characteristics of skin under compression: experiment and analysis. Biomed Mater Eng. 13(4):373-85. PubMed

2002

Waldman, S. D., Grynpas, M. D., Pilliar, R. M. et Kandel, R. A. (2002). Characterization of cartilagenous tissue formed on calcium polyphosphate substrates in vitro. J Biomed Mater Res. 62(3): 323-30. PubMed

2001

Jarry C, Chaput C, Chenite A, Renaud MA, Buschmann M, Leroux JC. (2001) Effects of steam sterilization on thermogelling chitosan-based gels. J Biomed Mater Res. 58(1):127-35. PubMed